Isocinchomeronsaeure-5-hydrazid | 17874-31-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Isocinchomeronsaeure-5-hydrazid
• 英文别名: 5-(Hydrazinecarbonyl)pyridine-2-carboxylic acid
• CAS: 17874-31-6
• 化学式: C₇H₇N₃O₃
• mdl: MFCD20542755
• 分子量: 181.151
• InChiKey: FAMNZNADXIACJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Oxidized lipid detection
  申请人：KRATOS ANALYTICAL LIMITED

  公开号：US10948502B2

  公开（公告）日：2021-03-16

  The present invention is concerned with a method of extracting oxidized lipids from a lipid solution, the method comprising (a) a derivatisation step, comprising contacting a derivatisation agent with the lipid solution such that aldehydic oxidized lipids and/or α,β-unsaturated oxidised lipids, if present in the lipid solution, are derivatised to include an anionic group, and (b) an oxidised lipid capture step, in which nanoparticles are contacted with the lipid solution, wherein the nanoparticles capture anionic-group containing oxidised lipids. The invention also includes a method of extracting aldehydic oxidized phospholipids from a lipid solution, the method comprising (a) a derivatisation step, comprising introduction of a anionic group to aldehydic oxidized lipids and/or α,β-unsaturated oxidised lipids in the lipid solution, and (b) an oxidised lipid capture step, in which nanoparticles are contacted with the lipid solution, wherein the nanoparticles bind anionic-group containing oxidised lipids.

  本发明涉及一种从脂质溶液中提取氧化脂质的方法，该方法包括(a)衍生化步骤，包括将衍生化剂与脂质溶液接触，使脂质溶液中存在的醛氧化脂质和/或α、(b) 氧化脂质捕获步骤，其中纳米颗粒与脂质溶液接触，纳米颗粒捕获含有阴离子基团的氧化脂质。本发明还包括一种从脂溶液中提取醛氧化磷脂的方法，该方法包括：(a) 衍生化步骤，包括向脂溶液中的醛氧化脂和（或）α，β-不饱和氧化脂中引入阴离子基团；(b) 氧化脂捕获步骤，其中纳米颗粒与脂溶液接触，纳米颗粒结合含有阴离子基团的氧化脂。
• OXIDIZED LIPID DETECTION
  申请人：KRATOS ANALYTICAL LIMITED

  公开号：US20160349277A1

  公开（公告）日：2016-12-01

  The present invention is concerned with a method of extracting oxidized lipids from a lipid solution, the method comprising (a) a derivatisation step, comprising contacting a derivatisation agent with the lipid solution such that aldehydic oxidized lipids and/or α,β-unsaturated oxidised lipids, if present in the lipid solution, are derivatised to include an anionic group, and (b) an oxidised lipid capture step, in which nanoparticles are contacted with the lipid solution, wherein the nanoparticles capture anionic-group containing oxidised lipids. The invention also includes a method of extracting aldehydic oxidized phospholipids from a lipid solution, the method comprising (a) a derivatisation step, comprising introduction of a anionic group to aldehydic oxidized lipids and/or α,β-unsaturated oxidised lipids in the lipid solution, and (b) an oxidised lipid capture step, in which nanoparticles are contacted with the lipid solution, wherein the nanoparticles bind anionic-group containing oxidised lipids.
• [EN] OXIDIZED LIPID DETECTION<br/>[FR] DÉTECTION DE LIPIDES OXYDÉS
  申请人：KRATOS ANALYTICAL LTD

  公开号：WO2015121627A1

  公开（公告）日：2015-08-20

  The present invention is concerned with a method of extracting oxidized lipids from a lipid solution, the method comprising (a) a derivatisation step, comprising contacting a derivatisation agent with the lipid solution such that aldehydic oxidized lipids and/or α,β-unsaturated oxidised lipids, if present in the lipid solution, are derivatised to include an anionic group, and (b) an oxidised lipid capture step, in which nanoparticles are contacted with the lipid solution, wherein the nanoparticles capture anionic-group containing oxidised lipids. The invention also includes a method of extracting aldehydic oxidized phospholipids from a lipid solution, the method comprising (a) a derivatisation step, comprising introduction of a anionic group to aldehydic oxidized lipids and/or α,β-unsaturated oxidised lipids in the lipid solution, and (b) an oxidised lipid capture step, in which nanoparticles are contacted with the lipid solution, wherein the nanoparticles bind anionic-group containing oxidised lipids.