o-Fluorperoxybenzoesaeure | 13020-01-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: o-Fluorperoxybenzoesaeure
• 英文别名: Peroxybenzoic acid, 2-fluoro-；2-fluorobenzenecarboperoxoic acid
• CAS: 13020-01-4
• 化学式: C₇H₅FO₃
• 分子量: 156.113
• InChiKey: HZALGKIPMDRUNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Preparation of noroxymorphone from morphine
  申请人：Mallinckrodt, Inc. (a Delaware corporation)

  公开号：EP0158476A1

  公开（公告）日：1985-10-16

  3-O,N-(diethoxycarbonyl) normorphine, which may be prepared by reaction of morphine with ethyl chloroformate, is converted to 3-0,n-(diethoxycarbonyl) normorphinone, a novel compound, by oxidation. The novel normorphinone derivative is converted to 3-0,N-(diethoxycarbonyl) normorphinone dienol acetate, a second novel compound, by esterification with acetic anhydride or acetyl halide. A 14-hydroxy group is introduced into the novel dienol ester by oxidation with peroxy-acid. The resultant 3-0,N-(die- thoxycarbonyl)-14-hydroxy-normorphinone, a third novel compound, may be catalytically hydrogenated to produce 3-O,N-(diethoxycarbonyl)noroxymorphone. The latter intermediate may be converted to noroxymorphone by hydrolysis.

  3-O,N-(二乙氧基羰基)诺吗啡可通过吗啡与氯甲酸乙酯反应制备，通过氧化转化为 3-0,N-(二乙氧基羰基)诺吗啡酮，一种新型化合物。新型诺吗啡酮衍生物通过与乙酸酐或乙酰卤进行酯化反应，转化为 3-0,N-（二氧羰基）诺吗啡酮二烯醇乙酸酯，这是第二种新型化合物。 通过过氧酸的氧化作用，在新型二烯醇酯中引入 14-羟基。由此得到的 3-0,N-（二乙氧基羰基）-14-羟基-去甲吗啡酮是第三种新型化合物，可通过催化氢化生成 3-O,N-（二乙氧基羰基）去甲吗啡酮。后一种中间体可通过水解作用转化为去甲羟吗啡酮。
• METHOD FOR THE ENZYMATIC KINETIC RESOLUTION OF ACYLOXYALKYL THIOCARBONATES USED FOR THE SYNTHESIS OF ACYLOXYALKYL CARBAMATES
  申请人：XenoPort, Inc.

  公开号：EP2250143A2

  公开（公告）日：2010-11-17
• US5112975A
  申请人：——

  公开号：US5112975A

  公开（公告）日：1992-05-12
• [EN] ENANTIOMERICALLY RESOLVING ACYLOXYALKYL THIOCARBONATES USED IN SYNTHESIZING ACYLOXYALKYL CARBAMATE PRODRUGS<br/>[FR] RÉSOLUTION DES ÉNANTIOMÈRES DE THIOCARBONATES D'ACYLOXYALKYLE UTILISÉS DANS LA SYNTHÈSE DE PRÉCURSEURS DE CARBAMATES D'ACYLOXYALKYLE
  申请人：XENOPORT INC

  公开号：WO2009094569A2

  公开（公告）日：2009-07-30

  Methods of enzymatically resolving acyloxyalkyl thiocarbonates useful in the synthesis of acyloxyalkyl carbamates are disclosed. These carbamates can be coupled to drugs containing amines such as R-baclofen or S-pregabalin.