2-[([1,1'-biphenyl]-4-ylmethyl)-sulfonyl]-N-hydroxybenzamide | 213012-61-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[([1,1'-biphenyl]-4-ylmethyl)-sulfonyl]-N-hydroxybenzamide
• 英文别名: Benzamide, 2-[([1,1'-biphenyl]-4-ylmethyl)sulfonyl]-N-hydroxy-；N-hydroxy-2-[(4-phenylphenyl)methylsulfonyl]benzamide
• CAS: 213012-61-4
• 化学式: C₂₀H₁₇NO₄S
• 分子量: 367.425
• InChiKey: NPVUYQZBYDLGMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  91.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Sulfonyl aryl or heteroaryl hydroxamic acid compounds
  申请人：G. D. Searle & Co.,

  公开号：US20030191317A1

  公开（公告）日：2003-10-09

  A sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound in a MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.

  本发明涉及一种磺酰基芳香或杂芳环羟羧酸化合物，该化合物在抑制基质金属蛋白酶活性方面起作用，还涉及一种治疗方法，包括向与病理性基质金属蛋白酶活性相关病情的宿主投入考虑的磺酰基芳香或杂芳环羟羧酸化合物，其有效量抑制MMP酶活性。
• SULFONYL DIVALENT ARYL OR HETEROARYL HYDROXAMIC ACID COMPOUNDS
  申请人：——

  公开号：US20010020021A1

  公开（公告）日：2001-09-06

  A sulfonyl divalent aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated sulfonyl divalent aromatic or heteroaromatic ring hydroxamic acid compound in a MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.

  本文披露了一种磺酰基双价芳香或杂芳香环羟肟酸化合物，其可以抑制基质金属蛋白酶活性，同时也揭示了一种治疗过程，包括向患有与病理基质金属蛋白酶活性相关的病情的宿主中投与考虑的磺酰基双价芳香或杂芳香环羟肟酸化合物，其剂量具有抑制MMP酶活性的有效作用量。
• Sulfonyl divalent aryl or heteroaryl hydroxamic acid compounds
  申请人：——

  公开号：US20020103239A1

  公开（公告）日：2002-08-01

  A sulfonyl divalent aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated sulfonyl divalent aromatic or heteroaromatic ring hydroxamic acid compound in a MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.

  公开了一种特别能抑制基质金属蛋白酶活性的磺酰二价芳香族或杂芳环状羟肟酸化合物，以及一种治疗方法，该方法包括向患有与病理性基质金属蛋白酶活性有关的病症的宿主施用有效量的MMP酶抑制剂磺酰二价芳香族或杂芳环状羟肟酸化合物。
• US6380258B2
  申请人：——

  公开号：US6380258B2

  公开（公告）日：2002-04-30
• US6656954B2
  申请人：——

  公开号：US6656954B2

  公开（公告）日：2003-12-02