5-[[bis(2,2,3,3-tetrafluoropropoxy)phosphoryl-(3,5-dichloro-2-hydroxyphenyl)methyl]amino]-1H-pyrimidine-2,4-dione | 269393-07-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-[[bis(2,2,3,3-tetrafluoropropoxy)phosphoryl-(3,5-dichloro-2-hydroxyphenyl)methyl]amino]-1H-pyrimidine-2,4-dione
• CAS: 269393-07-9
• 化学式: C₁₇H₁₄Cl₂F₈N₃O₆P
• 分子量: 610.182
• InChiKey: ADALMHJSKNUBLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  37
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  126
• 氢给体数：
  4
• 氢受体数：
  15

反应信息

• 作为产物：
  描述：

  3,5-二氯水杨醛 以 乙醇 、 水 为溶剂， 反应 2.0h， 生成 5-[[bis(2,2,3,3-tetrafluoropropoxy)phosphoryl-(3,5-dichloro-2-hydroxyphenyl)methyl]amino]-1H-pyrimidine-2,4-dione
  参考文献：
  名称：

  5-Arylideneaminouracyls: IV. Phosphorylated derivatives and their biological activity

  摘要：

  It extension of the studies on the search for the new biologically active 5-aminouracyl derivatives, we synthesized by the reaction of dialkylphosphites with arylideneuracils respective aminomethylphosphonates. The high level of the antiviral and anti-mycobacterial activity of the target compounds correlates well with the physicochemical parameters characterizing their structure.

  DOI：

  10.1134/s1070363209080106

文献信息

• 5-Arylideneaminouracyls: IV. Phosphorylated derivatives and their biological activity
  作者：V. I. Krutikov、A. V. Erkin

  DOI：10.1134/s1070363209080106

  日期：2009.8

  It extension of the studies on the search for the new biologically active 5-aminouracyl derivatives, we synthesized by the reaction of dialkylphosphites with arylideneuracils respective aminomethylphosphonates. The high level of the antiviral and anti-mycobacterial activity of the target compounds correlates well with the physicochemical parameters characterizing their structure.