N-(5-chloro-4-oxo-2-pyrrolidin-1-yl-4H-quinazolin-3-yl)-2-(3,5-difluorophenyl)acetamide | 1086683-48-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N-(5-chloro-4-oxo-2-pyrrolidin-1-yl-4H-quinazolin-3-yl)-2-(3,5-difluorophenyl)acetamide
• 英文别名: N-(5-chloro-4-oxo-2-pyrrolidin-1-ylquinazolin-3-yl)-2-(3,5-difluorophenyl)acetamide
• CAS: 1086683-48-8
• 化学式: C₂₀H₁₇ClF₂N₄O₂
• 分子量: 418.83
• InChiKey: XUZXRZZKZROEHQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• NOVEL 2, 3-DIAMINO-QUINAZOLINONE DERIVATIVES AND THEIR MEDICAL USE
  申请人：Jessen Carsten

  公开号：US20100160315A1

  公开（公告）日：2010-06-24

  This invention relates to novel 2,3-diamino-quinazolinone derivatives having medical utility, to use of the 2,3-diamino-quinazolinone derivatives of the invention for the manufacture of a medicament, to pharmaceutical compositions comprising the 2,3-diamino-quinazolinone derivatives of the invention, and to methods of treating a disorder, disease or a condition of a subject, which disorder, disease or condition is responsive to activation of K v 7 channels.

  本发明涉及具有医疗用途的新型2,3-二氨基喹唑啉酮衍生物，涉及使用本发明的2,3-二氨基喹唑啉酮衍生物制造药物，涉及包含本发明的2,3-二氨基喹唑啉酮衍生物的制药组合物，以及涉及治疗与Kv7通道激活有关的主体的紊乱、疾病或状况的方法。
• Novel 2,3-diamino-quinazolinone derivatives and their medical use
  申请人：NeuroSearch A/S

  公开号：EP2465504A1

  公开（公告）日：2012-06-20

  This invention relates to novel 2,3-diamino-quinazolinone derivatives having medical utility, to use of the 2,3-diamino-quinazolinone derivatives of the invention for the manufacture of a medicament, to pharmaceutical compositions comprising the 2,3-diamino-quinazolinone derivatives of the invention, and to methods of treating a disorder, disease or a condition of a subject, which disorder, disease or condition is responsive to activation of Kv7 channels.

  本发明涉及具有医疗用途的新型 2,3-二氨基喹唑啉酮衍生物，涉及使用本发明的 2,3-二氨基喹唑啉酮衍生物制造药物，涉及包含本发明的 2,3-二氨基喹唑啉酮衍生物的药物组合物，还涉及治疗受试者的紊乱、疾病或病症的方法，该紊乱、疾病或病症对 Kv7 通道的激活有反应。
• US8178544B2
  申请人：——

  公开号：US8178544B2

  公开（公告）日：2012-05-15