methyl-2-methyl-5-phenylbenzo[b]pyrazolo[5,1-f][1,6]naphthyridine-1-carboxylate | 1428586-67-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: methyl-2-methyl-5-phenylbenzo[b]pyrazolo[5,1-f][1,6]naphthyridine-1-carboxylate
• 英文别名: Methyl 13-methyl-16-phenyl-2,14,15-triazatetracyclo[8.7.0.03,8.011,15]heptadeca-1,3,5,7,9,11,13,16-octaene-12-carboxylate；methyl 13-methyl-16-phenyl-2,14,15-triazatetracyclo[8.7.0.03,8.011,15]heptadeca-1,3,5,7,9,11,13,16-octaene-12-carboxylate
• CAS: 1428586-67-7
• 化学式: C₂₃H₁₇N₃O₂
• 分子量: 367.407
• InChiKey: IRRPCDXKBHPFNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  56.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-phenylethynyl-quinoline-3-carbaldehyde 在 potassium phosphate 、 silver trifluoromethanesulfonate 作用下， 以 乙醇 为溶剂， 反应 0.17h， 生成 methyl-2-methyl-5-phenylbenzo[b]pyrazolo[5,1-f][1,6]naphthyridine-1-carboxylate
  参考文献：
  名称：

  Convenient synthesis of benzo[b]pyrazolo[5,1-f][1,6]naphthyridines by silver triflate catalyzed three-component reaction of 2-alkynyl-3-formylquinolines, tosylhydrazine and carbonyl compounds

  摘要：

  Benzo[b]pyrazolo[5,1-f][1,6]naphthyridines were prepared by silver triflate catalyzed one-pot cyclization of tosylhydrazine, carbonyl compounds and 2-alkynyl-3-formylquinolines, which are available by Sonogashira reaction of 2-chloro-3-formylquinoline. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.02.060

文献信息

• Convenient synthesis of benzo[b]pyrazolo[5,1-f][1,6]naphthyridines by silver triflate catalyzed three-component reaction of 2-alkynyl-3-formylquinolines, tosylhydrazine and carbonyl compounds
  作者：Muhammad Zahid、Viktor O. Iaroshenko、Ashot S. Saghyan、Christine Fischer、Peter Langer

  DOI：10.1016/j.tet.2013.02.060

  日期：2013.4

  Benzo[b]pyrazolo[5,1-f][1,6]naphthyridines were prepared by silver triflate catalyzed one-pot cyclization of tosylhydrazine, carbonyl compounds and 2-alkynyl-3-formylquinolines, which are available by Sonogashira reaction of 2-chloro-3-formylquinoline. (C) 2013 Elsevier Ltd. All rights reserved.