diphenyl(2,4,6-triisopropylphenyl)phosphine oxide | 1448632-04-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diphenyl(2,4,6-triisopropylphenyl)phosphine oxide
• 英文别名: 2-Diphenylphosphoryl-1,3,5-tri(propan-2-yl)benzene；2-diphenylphosphoryl-1,3,5-tri(propan-2-yl)benzene
• CAS: 1448632-04-9
• 化学式: C₂₇H₃₃OP
• 分子量: 404.532
• InChiKey: PCYDGCZMQGTXLH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  Diphenylphosphine oxide 、 phenyl(2,4,6-triisopropylphenyl)iodonium trifluoromethanesulfonate 在 三乙胺 、 copper(l) chloride 作用下， 以 二氯甲烷 为溶剂， 反应 0.17h， 以99%的产率得到diphenyl(2,4,6-triisopropylphenyl)phosphine oxide
  参考文献：
  名称：

  Copper-Catalyzed P-Arylation via Direct Coupling of Diaryliodonium Salts with Phosphorus Nucleophiles at Room Temperature

  摘要：

  A new method for copper-catalyzed P-C bond formation through reaction of phosphorus nucleophiles with diaryliodonium salts at room temperature is described. Most target products are obtained with this method in high yields within a short reaction time of 10 min. It can be easily adapted to large-scale preparations. When unsymmetrical iodonium salts are employed, nucleophilic substitution occurs preferentially on the sterically hindered aromatic ring or the more electron-deficient ring.

  DOI：

  10.1021/jo4012199

文献信息

• Copper-Catalyzed P-Arylation via Direct Coupling of Diaryliodonium Salts with Phosphorus Nucleophiles at Room Temperature
  作者：Jian Xu、Pengbo Zhang、Yuzhen Gao、Yiyin Chen、Guo Tang、Yufen Zhao

  DOI：10.1021/jo4012199

  日期：2013.8.16

  A new method for copper-catalyzed P-C bond formation through reaction of phosphorus nucleophiles with diaryliodonium salts at room temperature is described. Most target products are obtained with this method in high yields within a short reaction time of 10 min. It can be easily adapted to large-scale preparations. When unsymmetrical iodonium salts are employed, nucleophilic substitution occurs preferentially on the sterically hindered aromatic ring or the more electron-deficient ring.