2-(1-(3-phenylpropyl)-1H-1,2,3-triazol-4-yl)propan-2-ol | 1133862-76-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(1-(3-phenylpropyl)-1H-1,2,3-triazol-4-yl)propan-2-ol
• 英文别名: 2-[1-(3-Phenylpropyl)triazol-4-yl]propan-2-ol
• CAS: 1133862-76-6
• 化学式: C₁₄H₁₉N₃O
• 分子量: 245.324
• InChiKey: HHDVUOMWGBFKID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  50.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-phenylpropyl azide 、 2-甲基-3-丁炔-2-醇 在 三乙胺 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以98%的产率得到2-(1-(3-phenylpropyl)-1H-1,2,3-triazol-4-yl)propan-2-ol
  参考文献：
  名称：

  Copper/HP20: Novel and Polymer-Supported Copper Catalyst for Huisgen Cycloaddition

  摘要：

  A polymer-supported copper catalyst (Cu/HP20) is easily prepared in water and effectively catalyzed the Huisgen cycloaddition between azides and terminal alkynes.

  DOI：

  10.3987/com-08-s(f)56

文献信息

• Copper-hydroxyacetophenone thiosemicarbazone complex on silica-coated magnetite nanoparticles as an efficient catalyst for three-component synthesis of 1,4-disubstituted 1,2,3-triazoles
  作者：Narjes Kaviani、Somayeh Behrouz、Abbas Ali Jafari、Mohammad Navid Soltani Rad

  DOI：10.1016/j.jorganchem.2024.123043

  日期：2024.3

  Synthesis, characterization, and application of copper-hydroxyacetophenone thiosemicarbazone complex immobilized on silica-coated magnetite nanoparticles (FeO@SiO-HAT-Cu(I)) as a novel magnetically retrievable nanocatalyst for the three-component synthesis of 1,4-disubstituted 1,2,3-triazoles are described. [Display omitted]

  二氧化硅包覆磁铁矿纳米颗粒（FeO@SiO-HAT-Cu(I)）固定铜-羟基苯乙酮缩氨基硫脲复合物的合成、表征及应用作为新型磁性可回收纳米催化剂用于1,4-二取代1的三组分合成描述了2,3-三唑。[显示省略]
• Cu/HP20-Catalyzed Solvent-Free Huisgen Cycloaddition at Ordinary Temperatures
  作者：Hironao Sajiki、Yoshiaki Kitamura、Kazumi Taniguchi、Tomohiro Maegawa、Yasunari Monguchi、Yukio Kitade

  DOI：10.3987/com-13-s(s)6

  日期：——

  We have developed an environmentally friendly and highly efficient solvent-free Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction using a polymer-supported copper catalyst (Cu/HP20). Substrates poorly soluble in common organic solvents are also applicable to the present cycloaddition reaction without any solvents and provide the corresponding 1,4-triazole in high yields.