{[1-({2-amino-[6-(4-nitrophenyl)sulfanyl]-9H-purin-9-yl}methyl)-2-methylcyclopropyl]oxy}methylphosphonic acid | 441785-66-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: {[1-({2-amino-[6-(4-nitrophenyl)sulfanyl]-9H-purin-9-yl}methyl)-2-methylcyclopropyl]oxy}methylphosphonic acid
• 英文别名: [1-[[2-amino-6-(4-nitrophenyl)sulfanylpurin-9-yl]methyl]-2-methylcyclopropyl]oxymethylphosphonic acid
• CAS: 441785-66-6
• 化学式: C₁₇H₁₉N₆O₆PS
• 分子量: 466.414
• InChiKey: VBJUNNKYGDQUCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  208
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• (+)-Ttrans-isomers of (1-phosphonomethoxy-2-alkylcyclopropyl)methyl nucleoside derivatives, process for the preparation of stereoisomers thereof, and use of antiviral agents thereof
  申请人：Choi Jong-Ryoo

  公开号：US20060111324A1

  公开（公告）日：2006-05-25

  The present invention relates to (+)-trans-isomers of (1-phosphonomethoxy-2-alkylcyclopropyl)methyl nucleoside derivatives of the formula (1) which are useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable saltss, hydrates, or solvates thereof, and processes for the preparation of stereoisomers of the compounds of the formula (1), and a composition for the treatment of viral diseases (particularly, against hepatitis B virus) comprising (+)-trans-isomer of the compound of the formula (1), pharmaceutically acceptable salt, hydrate, or solvate thereof as an active substance.

  本发明涉及公式（1）的（1-磷酸甲氧基-2-烷基环丙基）甲基核苷衍生物的（+）-顺式异构体，其可用作抗病毒剂（特别是对乙型肝炎病毒），其药学上可接受的盐，水合物或溶剂化物，以及制备公式（1）化合物的立体异构体的过程，以及一种用于治疗病毒性疾病（特别是对乙型肝炎病毒）的组合物，包括公式（1）化合物的（+）-顺式异构体，其药学上可接受的盐，水合物或溶剂化物作为活性物质。
• Nucleoside phosphonate derivatives useful in the treatment of HIV infections
  申请人：Averett R. Devron

  公开号：US20060052346A1

  公开（公告）日：2006-03-09

  The present invention relates to a method of treating HIV infections by administering a nucleoside phosphonate derivative represented by formula (1).

  本发明涉及通过给予由式（1）表示的核苷酸膦酸衍生物治疗HIV感染的方法。
• Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same
  申请人：——

  公开号：US20040063668A1

  公开（公告）日：2004-04-01

  The present invention relates to an acyclic nucleoside phosphonate derivative which is useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable salts, stereoisomers, and a process for the preparation thereof.

  本发明涉及一种无环核苷酸膦酸酯衍生物，其可用作抗病毒剂（特别是对乙型肝炎病毒），药学上可接受的盐，立体异构体以及其制备方法。
• NOVEL ACYCLIC NUCLEOSIDE PHOSPHONATE DERIVATIVES, SALTS THEREOF AND PROCESS FOR THE PREPARATION OF THE SAME
  申请人：LG Life Sciences Ltd

  公开号：EP1358198B1

  公开（公告）日：2010-08-25
• US7157448B2
  申请人：——

  公开号：US7157448B2

  公开（公告）日：2007-01-02