(R)-1-(2,3-difluro-6-nitrophenoxy)propan-2-yl formate | 1224733-24-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-1-(2,3-difluro-6-nitrophenoxy)propan-2-yl formate
• 英文别名: [(2R)-1-(2,3-difluoro-6-nitrophenoxy)propan-2-yl] formate
• CAS: 1224733-24-7
• 化学式: C₁₀H₉F₂NO₅
• 分子量: 261.182
• InChiKey: BOYINPPIUQYUKL-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  81.4
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  甲酸 、 (S)-1-(2,3-difluro-6-nitrophenoxy)propan-2-yl p-toluenesulfonate 在 三乙胺 作用下， 以 甲苯 为溶剂， 反应 6.0h， 以95%的产率得到(R)-1-(2,3-difluro-6-nitrophenoxy)propan-2-yl formate
  参考文献：
  名称：

  Inversion of secondary chiral alcohols in toluene with the tunable complex of R3NR′COOH

  摘要：

  The S(N)2 reaction of enantiomerically pure sulfonates with the tunable complex of R3N-R'COOH in toluene has been extensively studied. It was revealed that the molar ratio of the tertiary amines and carboxylic acids in the complex of R3NR'COOH is crucial for the S(N)2 reaction, and should be tuned for each sulfonate to give the best yield. Fifteen sulfonates 1 and 3-13 (Scheme 2) were prepared and transformed into 22 corresponding inverted esters 2 and 14-24 (Scheme 2) in good to high yields. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.12.028

文献信息

• Inversion of secondary chiral alcohols in toluene with the tunable complex of R3NR′COOH
  作者：Xiao-Xin Shi、Chun-Li Shen、Jian-Zhong Yao、Liang-Deng Nie、Na Quan

  DOI：10.1016/j.tetasy.2009.12.028

  日期：2010.3

  The S(N)2 reaction of enantiomerically pure sulfonates with the tunable complex of R3N-R'COOH in toluene has been extensively studied. It was revealed that the molar ratio of the tertiary amines and carboxylic acids in the complex of R3NR'COOH is crucial for the S(N)2 reaction, and should be tuned for each sulfonate to give the best yield. Fifteen sulfonates 1 and 3-13 (Scheme 2) were prepared and transformed into 22 corresponding inverted esters 2 and 14-24 (Scheme 2) in good to high yields. (C) 2010 Elsevier Ltd. All rights reserved.