1-(β-Aminoaethyl)-1,2,5,6-tetrahydropyridin | 27578-63-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-(β-Aminoaethyl)-1,2,5,6-tetrahydropyridin
• 英文别名: 2-(3,6-dihydro-2H-pyridin-1-yl)-ethylamine；2-(3,6-dihydro-2H-pyridin-1-yl)-ethylamine；2-(3,6-dihydro-2H-pyridin-1-yl)ethanamine
• CAS: 27578-63-8
• 化学式: C₇H₁₄N₂
• mdl: MFCD19206117
• 分子量: 126.202
• InChiKey: JALSTPIIDUJOKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.714
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(β-Aminoaethyl)-1,2,5,6-tetrahydropyridin 、 N-(2-hydroxyethyl)-2-cyclohexylethylamine hydrochloride 、 N,N'-羰基二咪唑 生成 1-(2-cyclohexylethyl)-1-(2-hydroxyethyl)-3-[2-(1,2,5,6-tetrahydropyridin-1-yl) ethyl] urea
  参考文献：
  名称：

  EP1172359

  摘要：

  公开号：

文献信息

• [EN] SULFONYLBENZODIAZEPINONE ACETAMIDES AS BRADYKININ ANTAGONISTS<br/>[FR] SULFONYLBENZODIAZEPINONE ACETAMIDES UTILISES COMME ANTAGONISTES DE LA BRADYKININE
  申请人：ELAN PHARM INC

  公开号：WO2004033436A1

  公开（公告）日：2004-04-22

  Disclosed are compounds, of formula (I) which are bradykinin antagonists and are useful to treat diseases or relieve adverse symptoms associated with disease conditions in mammals mediated by bradykinin. Certain of the compounds exhibit increased potency and are expected to also exhibit an increased duration of action.

  揭示了一些化合物，其化学式为（I），它们是激肽酶抑制剂，并可用于治疗或缓解哺乳动物中由激肽酶介导的疾病或与疾病状况相关的不良症状。其中一些化合物表现出增强的效力，并预计也将表现出延长的作用时间。
• [EN] SULFONYLQUINOXALONE ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ ANTAGONISTS<br/>[FR] DERIVES D'ACETAMIDE SULFONYLQUINOXALONE ET COMPOSES ASSOCIES EN TANT QU'ANTAGONISTES DE LA BRADYKININE
  申请人：ELAN PHARM INC

  公开号：WO2003093245A1

  公开（公告）日：2003-11-13

  Disclosed are sulfonylquinoxalone acetamide derivatives useful as bradykinin antagonists to relieve symptons, associated with bradykinin including pain, inflammation, bronchoconstriction, cerebral edema, etc.

  揭示了作为布雷金肽拮抗剂有用的磺酰基喹诺酮乙酰胺衍生物，可用于缓解与布雷金肽相关的症状，包括疼痛、炎症、支气管收缩、脑水肿等。
• 4-aryl-N-(alkylaminoalkyl, heterocyclicamino and
  申请人：A. H. Robins Company, Inc.

  公开号：US04960776A1

  公开（公告）日：1990-10-02

  Novel 4-aryl-N-[2-(dialkylamino and heterocyclicamino)alkyl]-1-piperazinecarboxamides of the formula: ##STR1## wherein B is oxygen or sulfur; Ar is selected from ##STR2## or 2, 3 or 4-pyridyl; X is selected from hydrogen, halogen, loweralkyl, loweralkoxy, amino, dimethylamino, nitro, trifluoromethyl, cyano, acetyl, acetylamino, aminocarbonyl, carboxy or loweralkylcarboxylic acid ester; Y is selected from hydrogen, halogen, loweralkyl, loweralkoxy, nitro, trifluoromethyl, cyano, acetylamino, aminocarbonyl, carboxy or loweralkyl carboxylic acid ester; Z is selected from hydrogen, loweralkyl or loweralkoxy; Q is selected from ##STR3## m is 1 to 3 inclusive; n is zero or 1; p is zero to 3 inclusive; R.sup.1, R.sup.2 and R.sup.3 are loweralkyl and may be the same or different, or R.sup.1 and R.sup.2 taken together with the adjacent nitrogen atom may be form a heterocyclic residue; and the pharmaceutically acceptable salts thereof are disclosed. The compounds are useful in a method of combating allergic response associated with anaphylactic sensitivity in animals and humans.

  该专利涉及一种化合物，其通式为：##STR1## 其中B为氧或硫；Ar选自##STR2##或2、3或4-吡啶基；X选自氢、卤素、低碳基、低碳氧基、氨基、二甲基氨基、硝基、三氟甲基、氰基、乙酰基、乙酰氨基、氨基羰基、羧基或低碳基羧酸酯；Y选自氢、卤素、低碳基、低碳氧基、硝基、三氟甲基、氰基、乙酰氨基、氨基羰基、羧基或低碳基羧酸酯；Z选自氢、低碳基或低碳氧基；Q选自##STR3## m为1至3，包括1和3；n为零或1；p为零至3，包括0和3；R1、R2和R3为低碳基，并且可以相同或不同，或者R1和R2与相邻的氮原子一起形成杂环残基；以及其药学上可接受的盐。这些化合物在动物和人类的过敏反应与过敏性休克敏感性相关的治疗方法中有用。
• Sulfonylbenzodiazepinone acetamides as bradykinin antagonists
  申请人：——

  公开号：US20040138208A1

  公开（公告）日：2004-07-15

  Disclosed are compounds, which are bradykinin antagonists and are useful to treat diseases or relieve adverse symptoms associated with disease conditions in mammals mediated by bradykinin. Certain of the compounds exhibit increased potency and are expected to also exhibit an increased duration of action.

  本发明涉及一种化合物，其是布雷金肽拮抗剂，可用于治疗哺乳动物中由布雷金肽介导的疾病或缓解与疾病状态相关的不良症状。其中某些化合物表现出增强的效力，并预计也会表现出增强的作用持续时间。
• Sulfonylquinoxalone acetamide derivatives as bradykinin antagonists
  申请人：——

  公开号：US20040147519A1

  公开（公告）日：2004-07-29

  Disclosed are sulfonylquinoxalone acetamide derivatives useful as bradykinin antagonists.

  本发明涉及一种作为Bradykinin拮抗剂有用的磺酰基喹喔啉乙酰胺衍生物。