7-Chloro-2-cyclopentyl-5-[3-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)-benzyloxy]-6-methyl-indan-1-one | 866823-98-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 7-Chloro-2-cyclopentyl-5-[3-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)-benzyloxy]-6-methyl-indan-1-one
• CAS: 866823-98-5
• 化学式: C₂₇H₃₂BClO₄
• 分子量: 466.813
• InChiKey: KCMSLUFKFQYPDH-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  7-Chloro-2-cyclopentyl-5-[3-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)-benzyloxy]-6-methyl-indan-1-one 、 alkaline earth salt of/the/ methylsulfuric acid 在 bis-triphenylphosphine-palladium(II) chloride 、 potassium carbonate 、 lithium hydroxide 作用下， 以 甲醇 、 甲苯 、 四氢呋喃 为溶剂， 反应 66.0h， 生成 3'-{[(7-chloro-2-cyclopentyl-6-methyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy]methyl}-5-fluorobiphenyl-3-carboxylic acid
  参考文献：
  名称：

  Biphenyl-indanones: Allosteric potentiators of the metabotropic glutamate subtype 2 receptor

  摘要：

  We have identified and synthesized a series of biphenyl-carboxylic acid indanones as allosteric potentiators of the metabotropic glutamate receptor 2. Structure-activity relationship studies directed toward improving the potency and the brain to plasma ratio of the initial lead led to the discovery of 5 and 23 (EC50 = 111 and 5 nM, respectively). (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.06.062
• 作为产物：
  描述：

  7-Chloro-2-cyclopentyl-5-hydroxy-6-methyl-indan-1-one 、 3-溴甲基苯硼酸新戊二醇酯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 18.0h， 生成 7-Chloro-2-cyclopentyl-5-[3-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)-benzyloxy]-6-methyl-indan-1-one
  参考文献：
  名称：

  Biphenyl-indanones: Allosteric potentiators of the metabotropic glutamate subtype 2 receptor

  摘要：

  We have identified and synthesized a series of biphenyl-carboxylic acid indanones as allosteric potentiators of the metabotropic glutamate receptor 2. Structure-activity relationship studies directed toward improving the potency and the brain to plasma ratio of the initial lead led to the discovery of 5 and 23 (EC50 = 111 and 5 nM, respectively). (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.06.062