(22E,24S)-3β-chloro-5α-ergost-22-en-6-one | 85706-99-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (22E,24S)-3β-chloro-5α-ergost-22-en-6-one
• 英文别名: (3S,5S,8S,9S,10R,13R,14S,17R)-3-chloro-17-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-10,13-dimethyl-1,2,3,4,5,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-6-one
• CAS: 85706-99-6
• 化学式: C₂₈H₄₅ClO
• 分子量: 433.118
• InChiKey: YMHFKAGSCRHVTB-LVDAEEOTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (22E,24S)-3β-chloro-5α-ergost-22-en-6-one 在 lithium bromide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以240 mg的产率得到(22E,24R)-5α-ergosta-2,22-dien-6-one
  参考文献：
  名称：

  Anastasia, Mario; Ciuffreda, Pierangela; Fiecchi, Alberto, Journal of the Chemical Society. Perkin transactions I, 1983, # 2, p. 379 - 382

  摘要：

  DOI：
• 作为产物：
  描述：

  (22E)-3α,5-cyclo-5α-ergost-22-en-6-one 在 盐酸 作用下， 以 溶剂黄146 为溶剂， 反应 0.17h， 以500 mg的产率得到(22E,24S)-3β-chloro-5α-ergost-22-en-6-one
  参考文献：
  名称：

  Anastasia, Mario; Ciuffreda, Pierangela; Fiecchi, Alberto, Journal of the Chemical Society. Perkin transactions I, 1983, # 2, p. 379 - 382

  摘要：

  DOI：

文献信息

• Anastasia, Mario; Ciuffreda, Pierangela; Puppo, Marina Del, Journal of the Chemical Society. Perkin transactions I, 1983, # 2, p. 383 - 386
  作者：Anastasia, Mario、Ciuffreda, Pierangela、Puppo, Marina Del、Fiecchi, Alberto

  DOI：——

  日期：——
• Activity of brassinosteroids in the dwarf rice lamina inclination bioassay
  作者：Shozo Fujioka、Takahiro Noguchi、Suguru Takatsuto、Shigeo Yoshida

  DOI：10.1016/s0031-9422(98)00412-9

  日期：1998.12

  Biological activities of brassinolide, its biosynthetic intermediates and some biosynthetically related brassinosteroids were evaluated using modified dwarf rice lamina inclination bioassay. A very strong synergistic effect was observed when IAA was applied together with brassinosteroid. In particular co-application of brassinosteroid and 5 mu g IAA was ca. 300 times more active than a single application of brassinosteroid. Under co-application of 5 mu g IAA, the minimum detectable amount of brassinolide was less than 0.01 ng/rice plant. Biological activity increased according to the order of the biosynthetic pathway. Brassinosteroids in the early C-6 oxidation pathway (6-oxobrassinosteroids) were more active than corresponding brassinosteroids in the late C-6 oxidation pathway (6-deoxobrassinosteroids). Even very early biosynthetic intermediates such as campestanol showed some activity in our modified bioassay. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.