3-Benzyl-3-methyl-milchsaeure | 104296-22-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Benzyl-3-methyl-milchsaeure
• 英文别名: 2-Hydroxy-3-methyl-4-phenylbutanoic acid
• CAS: 104296-22-2
• 化学式: C₁₁H₁₄O₃
• 分子量: 194.23
• InChiKey: IICFAVSYXAKHGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• HIV PROTEASE INHIBITORS, COMPOSITIONS CONTAINING THE SAME, THEIR PHARMACEUTICAL USES, MATERIALS FOR THEIR SYNTHESIS
  申请人：Kucera John David

  公开号：US20070066664A1

  公开（公告）日：2007-03-22

  Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.

  本文披露了以下公式的化合物：其中公式变量如本文所定义，有利地抑制或阻断HIV蛋白酶的生物活性。这些化合物以及含有这些化合物的药物组合物，对于治疗感染HIV病毒的患者或宿主非常有用。还描述了制备这些化合物的中间体和合成方法。
• NOVEL PEPTIDES AS NS3-SERINE PROTEASE INHIBITORS OF HEPATITIS C VIRUS
  申请人：Saksena Anil K.

  公开号：US20110117057A1

  公开（公告）日：2011-05-19

  The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

  本发明披露了具有HCV蛋白酶抑制活性的新化合物，以及制备这些化合物的方法。在另一种实施方式中，本发明披露了包含这些化合物的制药组合物，以及使用它们治疗与HCV蛋白酶相关的疾病的方法。
• Heat-resistant resin composition
  申请人：KONISHI CO., LTD.

  公开号：EP0566780A1

  公开（公告）日：1993-10-27

  Disclosed is a heat-resistant resin composition prepared by mixing (A) a resin composition and (B) a hardener of an epoxy resin, followed by heating the mixture for curing, said composition (A) being prepared by heating a mixture of (a) a polymaleimide resin represented by the following general formula: (wherein R₁ represents an organic group having a valency of n, Xa and Xb represent monovalent atoms or groups which are the same or different and selected from a hydrogen atom, a halogen atom, and an organic group, and n represents 1 to 4), (b) an epoxy resin having at least two epoxy groups in a molecule thereof, and (c) a compound containing at least one hydroxyl group, at least one carboxyl group, or both at least one hydroxyl group and at least one carboxyl group in a molecule thereof.

  本发明公开了一种耐热树脂组合物，其制备方法是混合(A)树脂组合物和(B)环氧树脂固化剂，然后加热混合物使其固化，所述组合物(A)的制备方法是加热(a)由以下通式表示的聚马来酰亚胺树脂的混合物： (其中，R₁ 代表化合价为 n 的有机基团，Xa 和 Xb 代表选自氢原子、卤素原子和有机基团的相同或不同的单价原子或基团，n 代表 1 至 4）、(c) 分子中含有至少一个羟基、至少一个羧基或至少一个羟基和至少一个羧基的化合物。
• Leukotriene antagonists
  申请人：MERCK FROSST CANADA INC.

  公开号：EP0206741B1

  公开（公告）日：1991-04-10
• US7169932B2
  申请人：——

  公开号：US7169932B2

  公开（公告）日：2007-01-30