N-Ethyl-2,4-bis(trifluoromethyl)benzenemethanamine | 1199775-15-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-Ethyl-2,4-bis(trifluoromethyl)benzenemethanamine
• 英文别名: N-[[2,4-bis(trifluoromethyl)phenyl]methyl]ethanamine
• CAS: 1199775-15-9
• 化学式: C₁₁H₁₁F₆N
• 分子量: 271.2
• InChiKey: JAIMXKJJVGKNKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• PRODRUGS OF FUSED-BICYCLIC C5aR ANTAGONISTS
  申请人：CHEMOCENTRYX, INC.

  公开号：US20190300526A1

  公开（公告）日：2019-10-03

  The present disclosure provides, inter alia, Compounds of Formulae IA, IB, IC, IIA, IIB and IIC or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.

  本公开提供了化合物IA、IB、IC、IIA、IIB和IIC的结构，或其在药学上可接受的盐，这些化合物是C5a受体的调节剂。还提供了包括治疗涉及C5a病理性激活的疾病或疾病的药物组合物和使用方法，以及非药物应用。
• [EN] PRODRUGS OF FUSED-BICYCLIC C5aR ANTAGONISTS<br/>[FR] PROMÉDICAMENTS D'ANTAGONISTES DE C5AR BICYCLIQUES FUSIONNÉS
  申请人：CHEMOCENTRYX INC

  公开号：WO2019195159A1

  公开（公告）日：2019-10-10

  The present disclosure provides, inter alia, Compounds of Formulae IA, IB, IC, IIA, IIB and IIC or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.