N-[3-(dimethylsulfamoyl)phenyl]-6-oxo-7-(4-propan-2-yloxyphenyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide | 1198413-84-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[3-(dimethylsulfamoyl)phenyl]-6-oxo-7-(4-propan-2-yloxyphenyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide
• CAS: 1198413-84-1
• 化学式: C₂₅H₂₆N₄O₅S
• 分子量: 494.571
• InChiKey: CDUNGLSMNJTRBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  120
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Methods for Treating Acute Myocardial Infarctions and Associated Disorders
  申请人：Olgin Jeff

  公开号：US20110218515A1

  公开（公告）日：2011-09-08

  The invention relates to methods of treating patients who have suffered an acute myocardial infarction (AMI) with a therapeutic that has anti-fibrotic effects, for example, pirfenidone and analogs thereof.
• METHODS OF TREATING HIV PATIENTS WITH ANTI-FIBROTICS
  申请人：Kossen Karl

  公开号：US20120014917A1

  公开（公告）日：2012-01-19

  The invention relates to methods of treating patients infected with human immunodeficiency virus (HIV) with a therapeutic that has anti-fibrotic effects, for example, pirfenidone and analogs thereof.
• COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY AND FIBROTIC DISORDERS
  申请人：INTERMUNE, INC.

  公开号：US20130102597A1

  公开（公告）日：2013-04-25

  Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.
• US8969347B2
  申请人：——

  公开号：US8969347B2

  公开（公告）日：2015-03-03
• US9290450B2
  申请人：——

  公开号：US9290450B2

  公开（公告）日：2016-03-22