2-methyl-2-(2-methyl-4-{1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethylsulfanyl}-phenoxy)-propionic acid | 447407-24-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methyl-2-(2-methyl-4-{1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethylsulfanyl}-phenoxy)-propionic acid
• 英文别名: 2-Methyl-2-[2-methyl-4-[1-[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]ethylsulfanyl]phenoxy]propanoic acid
• CAS: 447407-24-1
• 化学式: C₂₄H₂₄F₃NO₃S₂
• 分子量: 495.587
• InChiKey: MEAQHQOZORFODX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• Thiazole derivatives for treating ppar related disorders
  申请人：——

  公开号：US20040063964A1

  公开（公告）日：2004-04-01

  The present invention provides compounds of formula (I). These compounds are used for the treatment of PPAR related diseases. 1

  本发明提供了式(I)的化合物。这些化合物用于治疗与PPAR相关的疾病。
• [EN] THIAZOLE DERIVATIVES FOR TREATING PPAR RELATED DISORDERS<br/>[FR] DERIVES THIAZOLE DESTINES AU TRAITEMENT DE TROUBLES ASSOCIES A DES RECEPTEURS PPAR
  申请人：GLAXO GROUP LTD

  公开号：WO2002062774A1

  公开（公告）日：2002-08-15

  The present invention provides compounds of formula (I). These compounds are used for the treatment of PPAR related diseases.

  本发明提供了式(I)的化合物。这些化合物用于治疗与PPAR相关的疾病。
• THIAZOLE DERIVATIVES FOR TREATING PPAR RELATED DISORDERS
  申请人：Cadilla Rodolfo

  公开号：US20060276519A1

  公开（公告）日：2006-12-07

  The present invention provides combinations of compounds of formula (I) and other therapeutic agents for the treatment of PPAR related diseases.

  本发明提供了式(I)化合物和其他治疗剂的组合物，用于治疗与PPAR相关的疾病。
• THIAZOLE DERIVATIVES FOR TRAEING PPAR RELATED DISORDERS
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1343773B1

  公开（公告）日：2006-11-02
• Thiazole Compound (as PPAR delta) Ligand and Pharmaceutical, Cosmetic and Health Food Comprised Thereof
  申请人：Kang Heonjoong

  公开号：US20100041723A1

  公开（公告）日：2010-02-18

  The present invention relates to a thiazole compound as a peroxisome proliferator activated receptor δ (PPARδ) activator or pharmaceutically acceptable salts thereof, and a pharmaceutical composition, a functional cosmetic composition, a health food, health beverages, a food additive and animal feeds containing the same.