dimethyl 3-[cyclohexyl-(3,4-dichlorophenyl)methyl]-2-sulfanylidene-1H-imidazole-4,5-dicarboxylate | 742108-34-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dimethyl 3-[cyclohexyl-(3,4-dichlorophenyl)methyl]-2-sulfanylidene-1H-imidazole-4,5-dicarboxylate
• CAS: 742108-34-5
• 化学式: C₂₀H₂₂Cl₂N₂O₄S
• 分子量: 457.378
• InChiKey: LLCCBYLSXKQOOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  100
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• CELL BASED ASSAYS FOR THE TRIGLYCERIDE SYNTHESIS PATHWAY
  申请人：Janssen Pharmaceutica NV

  公开号：EP2393938B1

  公开（公告）日：2015-08-05
• US9012159B2
  申请人：——

  公开号：US9012159B2

  公开（公告）日：2015-04-21
• [EN] CELL BASED ASSAYS FOR THE TRIGLYCERIDE SYNTHESIS PATHWAY<br/>[FR] TESTS CELLULAIRES POUR LA VOIE DE LA SYNTHÈSE DE TRIGLYCÉRIDE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2010091041A1

  公开（公告）日：2010-08-12

  A method for identifying a compound which modulates the activity of acyl-coA: diacylglycerol acyltransferase comprises the steps of contacting a stable isotope labeled fatty acid with cells in either presence or absence of the compound, extracting the cells with isopropyl alcohol, and determining the level of a stable isotope labeled triglyceride in the presence or absence of the compound; wherein a change in the level of the stable isotope labeled triglyceride indicates that the compound modulates the DGAT activity.