4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzene-1-sulfonamidehydrochloride | 2173013-44-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzene-1-sulfonamidehydrochloride
• 英文别名: 4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide;hydrochloride
• CAS: 2173013-44-8
• 化学式: C9H11ClN4O2S2
• 分子量: 306.8
• InChiKey: RJIMHIZAMHWQSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.65
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  135
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Pharmaceutical preparation containing copolyvidone
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US10098866B2

  公开（公告）日：2018-10-16

  A stabilized preparation which comprises: a unstable drug in a polyethylene glycol-containing preparation; and a coating agent comprising a copolyvidone instead of polyethylene glycol with which the drug is coated.

  一种稳定的制剂，包括：在聚乙二醇含制剂中的不稳定药物；以及一种包衣剂，其包衣剂包括一种共聚维酮，而不是用聚乙二醇包衣药物。
• Stabilized pharmaceutical composition
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0901787A1

  公开（公告）日：1999-03-17

  A stabilized pharmaceutical preparation which is coated with a coating agent comprising an agent for the protection from light, said agent being capable of producing free radicals when exposed to ultraviolet rays, and a free radical scavenger; which is stable to light, especially ultraviolet rays, or heat, and which has excellent storage-stability.

  一种稳定的药物制剂，其表面涂有一种包衣剂，该包衣剂包括一种避光剂（所述避光剂在紫外线照射下能产生自由基）和一种自由基清除剂；该制剂对光（尤其是紫外线）或热稳定，且具有极佳的储存稳定性。
• METHOD FOR PRODUCING PREPARATION CONTAINING BIOACTIVE SUBSTANCE
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1346722A1

  公开（公告）日：2003-09-24

  A method for producing a preparation containing a bioactive substance, characterized in that it comprises forming a solid material containing the bioactive substance and a polymer, and contacting the solid material with a high pressure gas. The method allows the production of a preparation which is suppressed in excessive initial release of the bioactive substance immediately after the administration thereof, is capable of releasing a predetermined amount of the bioactive substance over a long period of time, and is extremely reduced in the deterioration of the bioactive substance and in the amount of a residual organic solvent.

  一种生产含有生物活性物质的制剂的方法，其特征在于该方法包括形成含有生物活性物质和聚合物的固体材料，并使固体材料与高压气体接触。该方法可以生产出一种制剂，在服用后立即抑制生物活性物质的过度释放，能够在很长一段时间内释放预定量的生物活性物质，并极大地减少生物活性物质的变质和有机溶剂的残留量。
• PHARMACEUTICAL PREPARATION CONTAINING COPOLYVIDONE
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1334732A1

  公开（公告）日：2003-08-13

  A stabilized preparation which comprises: a unstable drug in a polyethylene glycol-containing preparation; and a coating agent comprising a copolyvidone instead of polyethylene glycol with which the drug is coated.

  一种稳定制剂，包括：含聚乙二醇制剂中的不稳定药物；以及由共聚维酮代替聚乙二醇组成的包衣剂，药物用其包衣。
• METHOD OF MANUFACTURING TABLET
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1405621A1

  公开（公告）日：2004-04-07

  A method of manufacturing a tablet containing coated granules comprising compressing the coated granules containing biologically active substance and having a temperature exceeding a room temperature, whereby the tablet can be prevented from rupture of a part of a coating film of the granules at the time of tablet compression.

  一种制造含有包衣颗粒的片剂的方法，包括压缩含有生物活性物质且温度超过室温的包衣颗粒，从而防止片剂在压缩时颗粒包衣膜的一部分破裂。