[3-{(2S)-[(cyclopropanecarbonyl-amino)-methyl]-pyrrolidin-1-yl}-(1R)-(2-fluoro-benzyl)-propyl]-carbamic acid tert-butyl ester | 871130-72-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [3-{(2S)-[(cyclopropanecarbonyl-amino)-methyl]-pyrrolidin-1-yl}-(1R)-(2-fluoro-benzyl)-propyl]-carbamic acid tert-butyl ester
• 英文别名: tert-butyl N-[(2R)-4-[(2S)-2-[(cyclopropanecarbonylamino)methyl]pyrrolidin-1-yl]-1-(2-fluorophenyl)butan-2-yl]carbamate
• CAS: 871130-72-2
• 化学式: C₂₄H₃₆FN₃O₃
• 分子量: 433.567
• InChiKey: NRGGYVGONSSNFR-PMACEKPBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  31
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  70.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (1R)-[(2-fluoro-benzyl)-3-oxo-propyl]-carbamic acid tert-butyl ester 、 N-[[(2S)-pyrrolidin-2-yl]methyl]cyclopropanecarboxamide 在 三乙酰氧基硼氢化钠 、 原甲酸三乙酯 作用下， 以 1,1-二氯乙烷 为溶剂， 生成 [3-{(2S)-[(cyclopropanecarbonyl-amino)-methyl]-pyrrolidin-1-yl}-(1R)-(2-fluoro-benzyl)-propyl]-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Dpp-IV Inhibitors

  摘要：

  该发明涉及式(I)的化合物，其中R1-9、Z、n、X、A和Rb的含义如描述和权利要求中所述。所述化合物可用作DPP-IV抑制剂。该发明还涉及制备这种化合物以及将其作为药物用于治疗2型糖尿病、肥胖和脂质紊乱的生产和使用。

  公开号：

  US20080176838A1

文献信息

• 1-¬(3R)-Amino-4-(2-fluoro-phenyl)-butyl|-pyrrolidine-(2R)-carboxylic acid benzyl amine derivatives and related compounds as dipeptidyl peptidase IV (DPP-IV) inhibitors for the treatment of type 2 diabetes mellitus
  申请人：Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft

  公开号：EP1604662A8

  公开（公告）日：2006-04-12

  The invention relates to compounds of formula (I) wherein R1-9, Z, n, X, A, and Rb have the meaning as cited in the description and the claims. Said compounds are useful as DPP-IV inhibitors. The invention also relates to the preparation of such compounds as well as the production and use thereof as medicament for the treatment of type 2 diabetes mellitus, obesity and lipid disorders.

  该发明涉及式（I）的化合物，其中R1-9、Z、n、X、A和Rb的含义如描述和权利要求中所述。所述化合物可用作DPP-IV抑制剂。该发明还涉及制备这类化合物以及将其作为药物用于治疗2型糖尿病、肥胖和脂质紊乱。
• 1-[(3R)-Amino-4-(2-fluoro-phenyl)-butyl]-pyrrolidine-(2R)-carboxylic acid benzyl amine derivatives and related compounds as dipeptidyl peptidase IV (DPP-IV) inhibitors for the treatment of type 2 diabetes mellitus
  申请人：Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft

  公开号：EP1604662A1

  公开（公告）日：2005-12-14

  The invention relates to compounds of formula (I) wherein R1-9, Z, n, X, A, and Rb have the meaning as cited in the description and the claims. Said compounds are useful as DPP-IV inhibitors. The invention also relates to the preparation of such compounds as well as the production and use thereof as medicament for the treatment of type 2 diabetes mellitus, obesity and lipid disorders.

  本发明涉及式 (I) 的化合物 其中 R1-9、Z、n、X、A 和 Rb 具有在说明书和权利要求书中引用的含义。所述化合物可用作 DPP-IV 抑制剂。本发明还涉及此类化合物的制备及其作为治疗 2 型糖尿病、肥胖症和血脂紊乱的药物的生产和使用。
• 1-[(3R)-AMINO-4-(2-FLUORO-PHENYL)-BUTYL]-PYRROLIDINE-(2R)-CARBOXYLIC ACID-BENZYL AMINE DERIVATIVES AND RELATED COMPOUNDS AS DIPEPTIDYL-PEPTIDASE IV (DPP-IV) INHIBITORS FOR THE TREATMENT OF TYPE 2 DIABETES MELLITUS
  申请人：Santhera Pharmaceuticals (Schweiz) AG

  公开号：EP1791536A1

  公开（公告）日：2007-06-06
• [EN] 1-`(3R)-AMINO-4-(2-FLUORO-PHENYL)-BUTYL !-PYRROLIDINE-(2R)-CARBOXILIC ACID-BENZYL AMINE DERIVATIVES AND RELATED COMPOUNDS AS DIPEPTIDYL-PEPTIDASE IV (DPP-IV) INHIBITORS FOR THE TREATMENT OF TYPE 2 DIABETES MELLITUS<br/>[FR] DERIVES DE 1-`(3R)-AMINO-4-(2-FLUORO-PHENYL)-BUTYL !-PYRROLIDINE-(2R)-ACIDE CARBOXILIQUE-BENZYLAMINE ET COMPOSES APPARENTES UTILISES COMME INHIBITEURS DE LA DIPEPTIDYL-PEPTIDASE IV (DPP-IV) DESTINES AU TRAITEMENT DU DIABETE NON INSULINO-DEPENDANT
  申请人：SANTHERA PHARMACEUTICALS DEUTS

  公开号：WO2005120494A1

  公开（公告）日：2005-12-22

  The invention relates to compounds of formula (I), wherein R<1-9>,< >Z, n, X, A, and R have the meaning as cited in the description and the claims. Said compounds are useful as DPP-IV inhibitors. The invention also relates to the preparation of such compounds as well as the production and use thereof as medicament for the treatment of type 2 diabetes mellitus, obesity and lipid disorders.
• Dpp-IV Inhibitors
  申请人：Edwards Paul John

  公开号：US20080176838A1

  公开（公告）日：2008-07-24

  The invention relates to compounds of formula (I) wherein R 1-9 , Z, n, X, A, and R b have the meaning as cited in the description and the claims. Said compounds are useful as DPP-IV inhibitors. The invention also relates to the preparation of such compounds as well as the production and use thereof as medicament for the treatment of type 2 diabetes mellitus, obesity and lipid disorders.

  该发明涉及式(I)的化合物，其中R1-9、Z、n、X、A和Rb的含义如描述和权利要求中所述。所述化合物可用作DPP-IV抑制剂。该发明还涉及制备这种化合物以及将其作为药物用于治疗2型糖尿病、肥胖和脂质紊乱的生产和使用。