N-(4,6-dichloro-pyrimidin-5-yl)-2-(2-iodo-phenyl)-acetamide | 1160608-63-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4,6-dichloro-pyrimidin-5-yl)-2-(2-iodo-phenyl)-acetamide
• 英文别名: N-(4,6-dichloropyrimidin-5-yl)-2-(2-iodophenyl)acetamide
• CAS: 1160608-63-8
• 化学式: C₁₂H₈Cl₂IN₃O
• 分子量: 408.026
• InChiKey: JGNUMYVLUYMMDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  54.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1
  申请人：Branstetter Bryan James

  公开号：US20090156599A1

  公开（公告）日：2009-06-18

  Certain TRPV1-modulating imidazolo-, oxazolo-, and thiazolopyrimdine compounds are described. The compounds may be used in pharmaceutical compositions and methods for treating disease states, disorders, and conditions mediated by TRPV1 activity, such as pain, arthritis, itch, cough, asthma, or inflammatory bowel disease.

  描述了某些调节TRPV1的咪唑基、噁唑基和噻唑吡啶化合物。这些化合物可用于制备药物组合物，并用于治疗由TRPV1活性介导的疾病状态、紊乱和症状，如疼痛、关节炎、瘙痒、咳嗽、哮喘或炎症性肠病。
• IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1
  申请人：Branstetter Bryan James

  公开号：US20130005687A1

  公开（公告）日：2013-01-03

  Certain TRPV1-modulating imidazolo-, oxazolo-, and thiazolopyrimdine compounds are described. The compounds may be used in pharmaceutical compositions and methods for treating disease states, disorders, and conditions mediated by TRPV1 activity, such as pain, arthritis, itch, cough, asthma, or inflammatory bowel disease.

  本文描述了某些调节TRPV1的咪唑啉、噁唑啉和噻唑嘧啶化合物。这些化合物可用于制备药物组合物和治疗TRPV1活性介导的疾病状态、紊乱和情况的方法，例如疼痛、关节炎、瘙痒、咳嗽、哮喘或炎症性肠病。
• PYRIDYLPHENOL COMPOUND AND USE THEREOF
  申请人：Sasaki Satoshi

  公开号：US20090156646A1

  公开（公告）日：2009-06-18

  The present invention provides a compound which has metastin receptor antagonist activity and is useful for preventing and treating hormone-dependent cancer, benign prostatomegaly, endometriosis, precocious puberty, uterine myoma or the like. More specifically, the present invention provides a compound, represented by the formula: or a salt thereof, a prodrug thereof, and a pharmaceutical agent containing the same; wherein Ring A represents a 5- to 8-membered homocyclic or heterocyclic group optionally having a substituent other than formula —X-R 1 wherein X represents a bond or a spacer, and R 1 represents optionally substituted amino or an optionally substituted nitrogen-containing heterocyclic group; Ring B represents an optionally substituted benzene ring; R 2 represents an optionally substituted homocyclic or heterocyclic group; and R 3 and R 4 independently represent a hydrogen atom, cyano, acyl or an optionally substituted hydrocarbon group.

  本发明提供了一种具有转移素受体拮抗活性的化合物，可用于预防和治疗激素依赖性癌症、良性前列腺增生、子宫内膜异位症、早熟、子宫肌瘤等。更具体地，本发明提供了一种化合物，其表示为以下公式：或其盐、前药及含有该化合物的药物制剂；其中环A表示一个5-至8-成员的同环或异环族群，可选地具有除公式—X-R1以外的取代基，其中X表示键或空间组分，而R1表示可选地取代的氨基或可选地取代的含氮杂环族群；环B表示可选地取代的苯环；R2表示可选地取代的同环或异环族群；而R3和R4独立地表示氢原子、氰基、酰基或可选地取代的碳氢基团。
• US8288397B2
  申请人：——

  公开号：US8288397B2

  公开（公告）日：2012-10-16
• US8637527B2
  申请人：——

  公开号：US8637527B2

  公开（公告）日：2014-01-28