9-Methyl-8-oxatetracyclo[7.2.1.17,10.01,6]tridec-2-en-4-one | 919286-04-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环己烷
• 英文名称: 9-Methyl-8-oxatetracyclo[7.2.1.17,10.01,6]tridec-2-en-4-one
• CAS: 919286-04-7
• 化学式: C₁₃H₁₆O₂
• 分子量: 204.269
• InChiKey: METIMLJPGCKFEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  9-Methyl-8-oxatetracyclo[7.2.1.17,10.01,6]tridecan-4-one 在 palladium diacetate 三甲基氯硅烷 、 六甲基二硅氮烷 、 lithium iodide 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 8.0h， 以60%的产率得到9-Methyl-8-oxatetracyclo[7.2.1.17,10.01,6]tridec-2-en-4-one
  参考文献：
  名称：

  基于手性池的板霉素合成。

  摘要：

  DOI：

  10.1002/anie.200705080

文献信息

• Novel Platensimycin Derivatives, Their Intermediates, and Process for Preparing the Same, and New Process for Preparing Platensimycin
  申请人：Lee Eun

  公开号：US20110028741A1

  公开（公告）日：2011-02-03

  The present invention relates to novel platensimycin derivatives, their intermediates and preparing methods of the same. Platensimycin is known as an effective antibiotic material having a broad antimicrobial spectrum and its derivatives are also expected to be effective antibiotic candidates. The present invention also relates to a novel preparing method of platensimycin. The intermediates used for the production of platensimycin and its derivatives of the present invention are tricyclo ketone derivatives and tetracyclo derivatives. Tetracyclo derivatives are prepared from tricyclo ketone derivatives prepared by carbonyl ylide [3+2] cycloaddition of dia-zoketone derivative.

  本发明涉及新型的platensimycin衍生物，它们的中间体以及相同的制备方法。已知Platensimycin是一种具有广泛抗菌谱的有效抗生素材料，其衍生物也被期望是有效的抗生素候选物。本发明还涉及一种新型的platensimycin制备方法。用于生产本发明的platensimycin及其衍生物的中间体是三环酮衍生物和四环衍生物。四环衍生物是由通过二氮杂酮衍生物的羰基亚烯[3+2]环加成反应制备的三环酮衍生物制备的。
• US8471043B2
  申请人：——

  公开号：US8471043B2

  公开（公告）日：2013-06-25
• [EN] NOVEL PLATENSIMYCIN DERIVATIVES, THEIR INTERMEDIATES, AND PROCESS FOR PREPARARING THE SAME, AND NEW PROCESS FOR PREPARING PLATENSIMYCIN<br/>[FR] NOUVEAUX DÉRIVÉS DE PLATENSIMYCINE, LEURS INTERMÉDIAIRES ET LEURS PROCÉDÉS DE PRÉPARATION, ET NOUVEAU PROCÉDÉ POUR PRÉPARER LA PLATENSIMYCINE
  申请人：SNU R&DB FOUNDATION

  公开号：WO2009125938A2

  公开（公告）日：2009-10-15

  The present invention relates to novel platensimycin derivatives, their intermediates and preparing methods of the same. Platensimycin is known as an effective antibiotic material having a broad antimicrobial spectrum and its derivatives are also expected to be effective antibiotic candidates. The present invention also relates to a novel preparing method of platensimycin. The intermediates used for the production of platensimycin and its derivatives of the present invention are tricyclo ketone derivatives and tetracyclo derivatives. Tetracyclo derivatives are prepared from tricyclo ketone derivatives prepared by carbonyl ylide [3+2] cycloaddition of dia- zoketone derivative