2-hydroxyamino-1-phenylethanone oxime | 25342-23-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-hydroxyamino-1-phenylethanone oxime
• 英文别名: 2-Hydroxyamino-1-phenylethanone oxime (E isomer)；(2E)-N-hydroxy-2-hydroxyimino-2-phenylethanamine；(NE)-N-[2-(hydroxyamino)-1-phenylethylidene]hydroxylamine
• CAS: 25342-23-8
• 化学式: C₈H₁₀N₂O₂
• 分子量: 166.18
• InChiKey: IOZXCKMKSKJISF-NTMALXAHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  64.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-hydroxyamino-1-phenylethanone oxime 以 甲醇 为溶剂， 反应 147.0h， 生成 2,3-Dimethyl-5-phenylpyrazine 1,4-Dioxide
  参考文献：
  名称：

  Reaction of 1,2-hydroxylaminooximes with 1,2-diketones. Conversion of 2-acyl-1-hydroxy-3-imidazoline 3-oxides to pyrazine 1,4-dioxides

  摘要：

  DOI：

  10.1007/bf00514993

文献信息

• Synthesis of 2-(3,4,5-trimethoxybenzoyl)-4(5)-phenyl-1H-imidazole
  作者：E. B. Nikolaenkova、I. A. Os’kina、A. Ya. Tikhonov

  DOI：10.1134/s1070428017120193

  日期：2017.12

  The condensation of (2E)-N-hydroxy-2-hydroxyimino-2-phenylethanamine with 3,4,5-trimethoxy-phenylglyoxal afforded (1-hydroxy-5-phenyl-1H-imidazol-2-yl)phenylmethanone which reacted with trimethyl phosphite or chloroacetone to give 2-(3,4,5-trimethoxybenzoyl)-4(5)-phenyl-1H-imidazole.
• Synthesis of nitroxyl radicals ? Derivatives of 5,5-dimethoxy-3-imidazoline-3-oxide-1-oxyl from 2H-imidazole 1,3-dioxides
  作者：I. A. Kirilyuk、I. A. Grigor'ev、L. B. Volodarskii

  DOI：10.1007/bf00960422

  日期：1991.9

  2H-Imidazole 1,3-dioxides containing an aldonitrone fragment in the heterocyclic ring are obtained by the oxidation of 5-unsubstituted 1-hydroxy-3-imidazoline 3-oxides. Their further oxidation by lead dioxide in methanol leads to the formation of stable nitroxyl radicals - 5,5-dimethoxy-3-imidazoline-3-oxide-1-oxyls.