N-(3-methylbenzo[b]thiophen-2-yl)-N-(4-trifluoromethoxy-benzyl)-2-(3,3,3-trifluoropropylamino)ethylsulfonamide | 1232141-66-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: N-(3-methylbenzo[b]thiophen-2-yl)-N-(4-trifluoromethoxy-benzyl)-2-(3,3,3-trifluoropropylamino)ethylsulfonamide
• 英文别名: N-(3-methyl-1-benzothiophen-2-yl)-N-[[4-(trifluoromethoxy)phenyl]methyl]-2-(3,3,3-trifluoropropylamino)ethanesulfonamide
• CAS: 1232141-66-0
• 化学式: C₂₂H₂₂F₆N₂O₃S₂
• 分子量: 540.551
• InChiKey: AAAGLIYLEAFRFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  95.3
• 氢给体数：
  1
• 氢受体数：
  12

文献信息

• SULFONAMIDES AS TRPM8 MODULATORS
  申请人：Macielag Mark J.

  公开号：US20100160289A1

  公开（公告）日：2010-06-24

  Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) and Formula (II) as follows: wherein Y, R 1 , R 2 , R 3 , R 4 , R A , and R B are defined herein.

  揭示了用于治疗各种疾病、综合症、症状和疾病的化合物、组合物和方法，包括疼痛。这些化合物由以下的化学式(I)和化学式(II)所代表：其中Y、R1、R2、R3、R4、RA和RB在此定义。
• US8148422B2
  申请人：——

  公开号：US8148422B2

  公开（公告）日：2012-04-03
• [EN] SULFONAMIDES AS TRPM8 MODULATORS<br/>[FR] SULFONAMIDES COMME MODULATEURS DE TRPM8
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2010080398A1

  公开（公告）日：2010-07-15

  Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) and Formula (II) as follows; wherein Y, R1, R2, R3, R4, RA, and RB are defined herein.