methyl (2R,4aR,9aR)-5-bromo-2-hydroxy-1,1,4a-trimethyl-2,3,4,4a,9,9a-hexahydro-1H-xanthene-7-carboxylate | 1353178-21-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 香豆素
• 英文名称: methyl (2R,4aR,9aR)-5-bromo-2-hydroxy-1,1,4a-trimethyl-2,3,4,4a,9,9a-hexahydro-1H-xanthene-7-carboxylate
• CAS: 1353178-21-8
• 化学式: C₁₈H₂₃BrO₄
• 分子量: 383.282
• InChiKey: NKFQIAKFQWFGLV-HBUWYVDXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.73
• 重原子数：
  23.0
• 可旋转键数：
  1.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  55.76
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  methyl (2R,4aR,9aR)-5-bromo-2-hydroxy-1,1,4a-trimethyl-2,3,4,4a,9,9a-hexahydro-1H-xanthene-7-carboxylate 在 manganese(IV) oxide 、 二异丁基氢化铝 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 3.25h， 生成 (2R,4aR,9aR)-5-bromo-2-(methoxymethoxy)-1,1,4a-trimethyl-2,3,4,4a,9,9a-hexahydro-1H-xanthene-7-carbaldehyde
  参考文献：
  名称：

  Relevance of the C-5 position to schweinfurthin induced cytotoxicity

  摘要：

  The schweinfurthins are an intriguing group of anti-proliferative agents that display low nanomolar activities against several cell types, including the human-derived glioblastoma cell line SF-295, but have little impact on other cell lines even at micromolar concentrations. This activity has inspired the synthesis of seven of the natural schweinfurthins, all with the correct absolute stereochemistry, and a variety of analogues designed to probe different facets of the pharmacophore. Reported herein is the synthesis of several new schweinfurthin analogues varied at the C-5 position along with data on their biological activity in the NCI 60 cell-line assay. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.10.034
• 作为产物：
  描述：

  methyl (2R,4aR,9aR)-2-acetoxy-5-bromo-1,1,4a-trimethyl-2,3,4,4a,9,9a-hexahydro-1H-xanthene-7-carboxylate 在 potassium carbonate 、 水 、 氯化铵 作用下， 以 甲醇 为溶剂， 以96%的产率得到methyl (2R,4aR,9aR)-5-bromo-2-hydroxy-1,1,4a-trimethyl-2,3,4,4a,9,9a-hexahydro-1H-xanthene-7-carboxylate
  参考文献：
  名称：

  Relevance of the C-5 position to schweinfurthin induced cytotoxicity

  摘要：

  The schweinfurthins are an intriguing group of anti-proliferative agents that display low nanomolar activities against several cell types, including the human-derived glioblastoma cell line SF-295, but have little impact on other cell lines even at micromolar concentrations. This activity has inspired the synthesis of seven of the natural schweinfurthins, all with the correct absolute stereochemistry, and a variety of analogues designed to probe different facets of the pharmacophore. Reported herein is the synthesis of several new schweinfurthin analogues varied at the C-5 position along with data on their biological activity in the NCI 60 cell-line assay. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.10.034