2-<2-Amino-ethyl>-benzoesaeure | 757901-30-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-<2-Amino-ethyl>-benzoesaeure
• 英文别名: 2-(2-Azaniumylethyl)benzoate
• CAS: 757901-30-7
• 化学式: C₉H₁₁NO₂
• mdl: MFCD07785893
• 分子量: 165.192
• InChiKey: OZCUCQLHGQMOAV-UHFFFAOYSA-N

物化性质

• 沸点：
  319.8±17.0 °C(Predicted)
• 密度：
  1.193±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-<2-Amino-ethyl>-benzoesaeure 在 水 作用下， 生成 3,4-二氢异喹啉-1(2H)-酮
  参考文献：
  名称：

  Bamberger; Dieckmann, Chemische Berichte, 1893, vol. 26, p. 1211

  摘要：

  DOI：
• 作为产物：
  描述：

  3,4-二氢异喹啉-1(2H)-酮 、 alkaline earth salt of/the/ methylsulfuric acid 生成 2-<2-Amino-ethyl>-benzoesaeure
  参考文献：
  名称：

  Bamberger; Dieckmann, Chemische Berichte, 1893, vol. 26, p. 1211

  摘要：

  DOI：

文献信息

• [EN] LIBRARIES OF PYRIDINE-CONTAINING MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME<br/>[FR] BIBLIOTHÈQUES DE COMPOSÉS MACROCYCLIQUES CONTENANT DE LA PYRIDINE ET LEURS PROCÉDÉS DE PRÉPARATION ET D'UTILISATION
  申请人：CYCLENIUM PHARMA INC

  公开号：WO2018232506A1

  公开（公告）日：2018-12-27

  The present disclosure relates to novel pyridine-containing macrocyclic compounds and libraries thereof that are useful as research tools for drug discovery efforts. This disclosure also relates to methods of preparing these compounds and libraries and methods of using these libraries, such as in high throughput screening. In particular, these libraries are useful for evaluation of bioactivity at existing and newly identified pharmacologically relevant targets, including G protein-coupled receptors, nuclear receptors, enzymes, ion channels, transporters, transcription factors, protein-protein interactions and nucleic acid-protein interactions. As such, these libraries can be applied to the search for new pharmaceutical agents for the treatment and prevention of a range of medical conditions.

  本公开涉及新型含吡啶的大环化合物及其库，这些化合物对药物发现工作是有用的研究工具。本公开还涉及制备这些化合物和库的方法，以及使用这些库的方法，例如在高通量筛选中。特别是，这些库对评估现有和新鉴定的药理学相关靶点的生物活性是有用的，包括G蛋白偶联受体、核受体、酶、离子通道、转运蛋白、转录因子、蛋白质相互作用和核酸-蛋白质相互作用。因此，这些库可应用于寻找用于治疗和预防各种医疗状况的新药物。
• LIBRARIES OF DIVERSE MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
  申请人：CYCLENIUM PHARMA INC.

  公开号：US20190153620A1

  公开（公告）日：2019-05-23

  The present disclosure relates to novel macrocyclic compounds and libraries thereof that are useful as research tools for drug discovery efforts. This disclosure also relates to methods of preparing these compounds and libraries and methods of using these libraries, such as in high throughput screening. In particular, these libraries are useful for evaluation of bioactivity at existing and newly identified pharmacologically relevant targets, including G protein-coupled receptors, nuclear receptors, enzymes, ion channels, transporters, transcription factors, protein-protein interactions and nucleic acid-protein interactions. As such, these libraries can be applied to the search for new pharmaceutical agents for the treatment and prevention of a range of medical conditions.

  本公开涉及新颖的大环化合物及其库，这些化合物可作为药物发现工作的研究工具。本公开还涉及制备这些化合物和库的方法，以及使用这些库的方法，例如在高通量筛选中的应用。特别是，这些库可用于评估现有和新鉴定的药理相关靶点的生物活性，包括G蛋白偶联受体、核受体、酶、离子通道、转运蛋白、转录因子、蛋白质相互作用和核酸-蛋白质相互作用。因此，这些库可应用于寻找用于治疗和预防各种医疗状况的新药物。
• [EN] LIBRARIES OF HETEROARYL-CONTAINING MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME<br/>[FR] BIBLIOTHÈQUES DE COMPOSÉS MACROCYCLIQUES CONTENANT HÉTÉROARYLE ET PROCÉDÉS POUR LEUR FABRICATION ET LEUR UTILISATION
  申请人：CYCLENIUM PHARMA INC

  公开号：WO2017049383A1

  公开（公告）日：2017-03-30

  The present disclosure relates to novel macrocyclic compounds and libraries thereof containing heteroaryl moieties that are useful as research tools for drug discovery efforts. The present disclosure also relates to methods of preparing these compounds and libraries and methods of using these libraries, such as in high throughput screening. In particular, these libraries are useful for evaluation of bioactivity at existing and newly identified pharmacologically relevant targets, including G protein-coupled receptors, nuclear receptors, enzymes, ion channels, transporters, transcription factors, protein-protein interactions and nucleic acid-protein interactions. As such, these libraries can be applied to the search for new pharmaceutical agents for the treatment and prevention of a range of medical conditions.

  本公开涉及新型大环化合物及其库，其中包含对药物发现工作有用的含杂环芳基团的化合物。本公开还涉及制备这些化合物和库的方法，以及使用这些库的方法，例如在高通量筛选中使用。特别是，这些库可用于评估现有和新鉴定的药理学相关靶点的生物活性，包括G蛋白偶联受体、核受体、酶、离子通道、转运蛋白、转录因子、蛋白质相互作用和核酸-蛋白质相互作用。因此，这些库可应用于寻找用于治疗和预防各种医疗状况的新药物。
• [EN] CHELATED PSMA INHIBITORS<br/>[FR] INHIBITEURS CHÉLATÉS DU PSMA
  申请人：CANCER TARGETED TECHNOLOGY LLC

  公开号：WO2012174136A1

  公开（公告）日：2012-12-20

  Compounds as defined herein are provided which are useful in (1) diagnostic methods for detecting and/or identifying cells presenting PSMA; (2) compositions comprising a compound of the invention together with a pharmaceutically acceptable diluent; and (3) methods for imaging prostate cancer cells.

  本文定义的化合物可用于：（1）用于检测和/或鉴定表达PSMA的细胞的诊断方法；（2）包含本发明化合物的与药用稀释剂一起的组合物；以及（3）用于成像前列腺癌细胞的方法。
• Amidite for nucleic acid synthesis and nucleic acid synthesizing method
  申请人：Fujihara Tsuyoshi

  公开号：US20080167459A1

  公开（公告）日：2008-07-10

  To provide an amidite for nucleic acid synthesis, which enables a protective group therein to be removed under moderate conditions and can be practically used, and a nucleic acid synthesizing method using the amidite for nucleic acid synthesis. Specifically, the present invention relates to an amidite for nucleic acid synthesis represented by General Formula (I) below, and a nucleic acid synthesizing method using the amidite for nucleic acid synthesis: where X denotes a base; Y denotes a protective group formed of any one of a 4-aminobutyric acid derivative, an o-aminomethylbenzoic acid derivative, an o-aminophenylacetic acid derivative, an o-aminoethylbenzoic acid derivative, an o-aminomethylphenylacetic acid derivative, an o-aminophenylpropionic acid derivative and a 5-aminovaleric acid derivative; and Q denotes one of a hydrogen atom and a hydroxyl group.

  提供一种用于核酸合成的酰胺，其使其中的保护基在温和条件下可以被去除并且可以实际应用，以及使用该核酸合成酰胺的核酸合成方法。具体来说，本发明涉及一种用下面的一般式（I）表示的用于核酸合成的酰胺，以及使用该核酸合成酰胺的核酸合成方法：其中X代表一种碱基；Y代表由4-氨基丁酸衍生物、o-氨基甲基苯甲酸衍生物、o-氨基苯乙酸衍生物、o-氨基乙基苯甲酸衍生物、o-氨基甲基苯乙酸衍生物、o-氨基苯丙酸衍生物和5-氨基戊酸衍生物中的任一形成的保护基；Q代表氢原子或羟基中的一个。