2-(4-nitro-phenyl)-3a,4,7,7a-tetrahydro-4,7-methano-isoindole-1,3-dione | 19077-62-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2-(4-nitro-phenyl)-3a,4,7,7a-tetrahydro-4,7-methano-isoindole-1,3-dione
• 英文别名: N-(p-Nitro-phenyl)-3,6-endomethylen-Δ⁴-tetrahydro-phthalsaeureimid；2-(4-nitrophenyl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione；4-(4-nitrophenyl)-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione
• CAS: 19077-62-4
• 化学式: C₁₅H₁₂N₂O₄
• mdl: MFCD00418234
• 分子量: 284.271
• InChiKey: KQEVIRDFQKXDCH-UHFFFAOYSA-N

物化性质

• 沸点：
  575.1±50.0 °C(Predicted)
• 密度：
  1.474±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  83.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-(4-硝基苯基)马来酰亚胺 、 环戊二烯 以 苯 为溶剂， 生成 2-(4-nitro-phenyl)-3a,4,7,7a-tetrahydro-4,7-methano-isoindole-1,3-dione
  参考文献：
  名称：

  Kiselev, V. D.; Sakhabutdinov, A. G.; Shakirov, I. M., Journal of Organic Chemistry USSR (English Translation), 1991, vol. 27, # 8.1, p. 1437 - 1443

  摘要：

  DOI：

文献信息

• [EN] FUSED CYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF, MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION<br/>[FR] COMPOSES D'IMIDES SUCCINIQUES CYCLIQUES ACCOLES ET LEURS ANALOGUES, MODULATEURS DE LA FONCTION DU RECEPTEUR D'HORMONES NUCLEAIRES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2002067939A1

  公开（公告）日：2002-09-06

  Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.

  融合环化合物，使用这种化合物治疗与核激素受体相关的疾病，如癌症和免疫紊乱的方法，以及包含这种化合物的制药组合物。
• Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
  申请人：——

  公开号：US20040087548A1

  公开（公告）日：2004-05-06

  Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.

  融合的环状化合物，使用这种化合物治疗与核激素受体相关的疾病，如癌症和免疫紊乱的方法，以及包含这种化合物的制药组合物。
• RING-OPENED POLYNORBORNENES
  申请人：JSR Corporation

  公开号：EP1561766A1

  公开（公告）日：2005-08-10

  The invention provides a ring-opened polynorbornene that is relatively low in birefringence, has specific wavelength dependency about birefringence and is excellent in transparency and heat resistance. [Solving means] The polymer of the present invention has a structural unit (I) of the general formula (I): [Chemical formula 1] wherein in the general formula (I), m and n are integers of 0 to 2, X1 is an ethylene or vinylene group, R1 and R2 are individually a hydrogen atom or a substituted or unsubstituted hydrocarbon group having 1 to 30 carbon atoms, and R3 is a group of the general formula (I-1) or (I-2), in which in the general formulae (I-1) and (I-2), R11 to R27 are individually a hydrogen atom; a halogen atom; a substituted or unsubstituted hydrocarbon group having 1 to 30 carbon atoms, which may have a linkage containing or not containing oxygen, sulfur, nitrogen and/or silicon atom(s); or a polar group, p and q in the general formula (I-1) are individually 0 or a positive integer, with the proviso that when both p and q are 0, R12 and R15, or R19 and R15 may be bonded to each other to form a carbon ring or heterocyclic ring, and the carbon ring or heterocyclic ring may be either a monocyclic structure or a polycyclic structure, and s in the general formula (I-2) is 0 or a positive integer.

  本发明提供了一种双折射相对较低、对双折射具有特定波长依赖性、透明度和耐热性优异的开环聚降冰片烯。 [解决方法】本发明的聚合物具有通式（I）的结构单元（I）： [化学式 1］ 其中在通式（I）中，m 和 n 是 0 至 2 的整数，X1 是乙烯基或乙烯基，R1 和 R2 分别是氢原子或具有 1 至 30 个碳原子的取代或未取代的烃基，R3 是通式（I-1）或（I-2）的基团，其中在通式（I-1）和（I-2）中，R11 至 R27 分别是氢原子；卤素原子； 具有 1 至 30 个碳原子的取代或未取代的烃基，该烃基可以具有含或不含氧、硫、氮和/或硅原子的连接；或极性基团，通式（I-1）中的 p 和 q 分别为 0 或正整数，但当 p 和 q 均为 0 时，R12 和 R15 或 R19 和 R15 可相互键合形成碳环或杂环，碳环或杂环可为单环结构或多环结构，通式（I-2）中的 s 为 0 或正整数。
• Ring-opened polynorbornenes
  申请人：Miyaki Nobuyuki

  公开号：US20060041092A1

  公开（公告）日：2006-02-23

  The invention provides a ring-opened polynorbornene that is relatively low in birefringence, has specific wavelength dependency about birefringence and is excellent in transparency and heat resistance. [Solving means] The polymer of the present invention has a structural unit (I) of the general formula (I): [Chemical formula 1 ] wherein in the general formula (I), m and n are integers of 0 to 2, X 1 is an ethylene or vinylene group, R 1 and R 2 are individually a hydrogen atom or a substituted or unsubstituted hydrocarbon group having 1 to 30 carbon atoms, and R 3 is a group of the general formula (I-1) or (I-2), in which in the general formulae (I-1) and (I-2), R 11 to R 27 are individually a hydrogen atom; a halogen atom; a substituted or unsubstituted hydrocarbon group having 1 to 30 carbon atoms, which may have a linkage containing or not containing oxygen, sulfur, nitrogen and/or silicon atom(s); or a polar group, p and q in the general formula (I-1) are individually 0 or a positive integer, with the proviso that when both p and q are 0, R 12 and R 15 , or R 19 and R 15 may be bonded to each other to form a carbon ring or heterocyclic ring, and the carbon ring or heterocyclic ring may be either a monocyclic structure or a polycyclic structure, and s in the general formula (I-2) is 0 or a positive integer.

  本发明提供了一种双折射相对较低、对双折射具有特定波长依赖性、透明度和耐热性优异的开环聚降冰片烯。[解决方法】本发明的聚合物具有通式（I）的结构单元（I）： [化学式 1 ] 其中，在通式（I）中，m 和 n 是 0 至 2 的整数，X 1 是乙烯基或乙烯基，R 1 和 R 2 分别是氢原子或具有 1 至 30 个碳原子的取代或未取代的烃基，以及 R 3 是通式（I-1）或（I-2）的基团，其中在通式（I-1）和（I-2）中，R 11 至 R 27 通式（I-1）中的 p 和 q 分别为 0 或正整数，但当 p 和 q 均为 0 时，R 12 和 R 15 或 R 19 和 R 15 可相互键合形成碳环或杂环，碳环或杂环可为单环结构或多环结构，通式 (I-2) 中的 s 为 0 或正整数。
• Kiselev, V. D.; Sakhabutdinov, A. G.; Shakirov, I. M., Journal of Organic Chemistry USSR (English Translation), 1991, vol. 27, # 8.1, p. 1437 - 1443
  作者：Kiselev, V. D.、Sakhabutdinov, A. G.、Shakirov, I. M.、Konovalov, A. I.

  DOI：——

  日期：——