1-(3-iodopropyl)-1H-pyrrole-2,5-dione | 697763-02-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(3-iodopropyl)-1H-pyrrole-2,5-dione
• 英文别名: 1-(3-Iodopropyl)pyrrole-2,5-dione
• CAS: 697763-02-3
• 化学式: C₇H₈INO₂
• 分子量: 265.051
• InChiKey: NTBWDGQVFFGHIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(3-iodopropyl)-1H-pyrrole-2,5-dione 、 5,10,15-trimethyl-5,10,15,20-tetra(4-pyridyl)porphyrin hexafluorophosphate 以 乙腈 为溶剂， 反应 144.0h， 以76%的产率得到5-propyl-1H-pyrrole-2,5-dione-10,15,20-trimethyl-5,10,15,20-tetra(4-pyridyl)porphyrin
  参考文献：
  名称：

  Synthesis of DNA Conjugates with Metalated Tetracationic Porphyrins by Postsynthetic Cycloadditions

  摘要：

  Tetracationic porphyrins of the TMPP (meso-tetra-(4-N-methylpyridyl)porphyrin) type, metalated with Cu(II) or with Au(III), were conjugated covalently to oligonucleotides. The Cu(I)-catalyzed cycloaddition (between an azide and an ethynyl group) and the Diels-Alder cycloaddition (between a furan and a maleimide functionality) were successfully applied as two alternative postsynthetic methods to modify the 2'-position of an internal uridine. Melting temperatures and UV/vis absorption properties were compared. CD measurements indicated that the type of conjugation chemistry determines the grade of intercalation of the attached and positively charged porphyrins.

  DOI：

  10.1021/ol500364j

文献信息

• Method for continuous detection of an analyte, trifunctional detecting reagent used and detecting device
  申请人：Volland Herve

  公开号：US20060160086A1

  公开（公告）日：2006-07-20

  The invention concerns a method for heterogeneous phase detection of an analyte, the trifunctional reagent used for implementing said method, its use for detecting an analyte, as well as the device for detecting a corresponding analyte

  这项发明涉及一种用于异质相检测分析物的方法，用于实施该方法的三功能试剂，其用于检测分析物的用途，以及用于检测相应分析物的设备
• [EN] FATTY ACID GAMMA AMINOBUTYRIC ACID (GABA) CONJUGATES AND THEIR USES<br/>[FR] CONJUGUÉS D'ACIDE GRAS ET D'ACIDE GAMMA-AMINOBUTYRIQUE (GABA) ET LEURS APPLICATIONS
  申请人：CATABASIS PHARMACEUTICALS INC

  公开号：WO2012161798A1

  公开（公告）日：2012-11-29

  The invention relates to fatty acid GABA conjugates; compositions comprising an effective amount of a fatty acid GABA conjugate; and methods for treating or preventing a metabolic disease or an inflammatory disorder comprising the administration of an effective amount of a fatty acid GABA conjugate.

  该发明涉及脂肪酸GABA共轭物；包含有效量脂肪酸GABA共轭物的组合物；以及用于治疗或预防代谢性疾病或炎症性疾病的方法，包括给予有效量脂肪酸GABA共轭物。
• PROCEDE DE DETECTION EN CONTINU D'UN ANALYTE, REACTIF TRIFONCTIONNEL DE DETECTION MIS EN OEUVRE ET DISPOSITIF DE DETECTION.
  申请人：COMMISSARIAT A L'ENERGIE ATOMIQUE

  公开号：EP1567865B1

  公开（公告）日：2006-11-15
• MULTISTEP TUMOR TARGETING BY TAGGED ANTIBODY DERIVATIVES AND TAGGED DRUGS
  申请人：ISTITUTO BIOCHIMICO ITALIANO GIOVANNI LORENZINI S.P.A

  公开号：US20200030455A1

  公开（公告）日：2020-01-30

  The present invention primarily relates to a novel, flexible, modular, multi-step, targeted and conditional drug targeting and delivery system. This system bypasses some general limitations of Antibody Drug Conjugates (ADCs) and widens the applicability of these key anticancer agents in precision medicine.
• [EN] MULTISTEP TUMOR TARGETING BY TAGGED ANTIBODY DERIVATIVES AND TAGGED DRUGS<br/>[FR] CIBLAGE DE TUMEUR EN PLUSIEURS ÉTAPES AU MOYEN DE DÉRIVÉS D'ANTICORPS MARQUÉS ET DE MÉDICAMENTS MARQUÉS
  申请人：ST BIOCHIMICO ITALIANO GIOVANNI LORENZINI S P A

  公开号：WO2018138676A1

  公开（公告）日：2018-08-02

  The present invention primarily relates to a novel, flexible, modular, multi-step, targeted and conditional drug targeting and delivery system. This system bypasses some general limitations of Antibody Drug Conjugates (ADCs) and widens the applicability of these key anticancer agents in precision medicine.