dimethyl [2-(benzo[1,4]dioxan-2-yl)-2-oxo]ethylphosphonate | 54442-10-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: dimethyl [2-(benzo[1,4]dioxan-2-yl)-2-oxo]ethylphosphonate
• 英文别名: 1-(2,3-dihydro-1,4-benzodioxin-3-yl)-2-dimethoxyphosphorylethanone
• CAS: 54442-10-3
• 化学式: C₁₂H₁₅O₆P
• 分子量: 286.221
• InChiKey: RXDHSAFBDFSGPE-UHFFFAOYSA-N

物化性质

• 沸点：
  410.9±45.0 °C(Predicted)
• 密度：
  1.304±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.88
• 重原子数：
  19.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  71.06
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  dimethyl [2-(benzo[1,4]dioxan-2-yl)-2-oxo]ethylphosphonate 在 sodium tetrahydroborate 、 sodium hydride 、 溶剂黄146 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 生成 5-[(3aS,4R,5R,6aS)-4-[(E)-(S)-3-(2,3-Dihydro-benzo[1,4]dioxin-2-yl)-3-hydroxy-propenyl]-5-hydroxy-hexahydro-pentalen-(2E)-ylidene]-pentanoic acid tert-butyl ester
  参考文献：
  名称：

  Synthesis and biological activity of novel carbacyclins having bicyclic substituents on the .omega.-chain

  摘要：

  A number of carbacyclins having bicyclic substituents on the omega-chain have been synthesized and tested for antiplatelet aggregation activity in vitro (against collagen-induced aggregation of rat platelet), for reduction of systemic blood pressure in vivo (ability to reduce the blood pressure in anesthetized rat by iv injection), and for cytoprotective activity (protection against ethanol-induced rat gastric lesion). The most effective compound for each activity was [3aS-[2E,3a alpha,4 alpha (3R),5 beta,6a alpha]]-5-[hexahydro-5- hydroxy-4-[3-hydroxy-3-(2-indanyl)-1-propynyl]-2(1H)-pentalenylidene+ ++] pentanoic acid (compound 11a), while some 1,4-benzodioxan analogues had selectivity for organ-protective activity, and indan analogues showed selectivity in their antiaggregation activity.

  DOI：

  10.1021/jm00128a049
• 作为产物：
  描述：

  1,4-苯并二噁烷-2-羧酸甲酯 、 甲基膦酸二甲酯 以68%的产率得到
  参考文献：
  名称：

  TSUYOSHI, TOMIYAMA;SHUICHI, WAKABAYASHI;MASAYUKI, YOKOTA, J. MED. CHEM., 32,(1989) N, C. 1988-1996

  摘要：

  DOI：