[2-trifluoromethyl-4-(2,2,2-trifluoro-acetylamino)-phenoxy]-(3-trifluoromethyl-phenyl)-acetic acid | 863423-06-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [2-trifluoromethyl-4-(2,2,2-trifluoro-acetylamino)-phenoxy]-(3-trifluoromethyl-phenyl)-acetic acid
• 英文别名: 2-[4-[(2,2,2-Trifluoroacetyl)amino]-2-(trifluoromethyl)phenoxy]-2-[3-(trifluoromethyl)phenyl]acetic acid
• CAS: 863423-06-7
• 化学式: C₁₈H₁₀F₉NO₄
• 分子量: 475.267
• InChiKey: VHZURVJIYDGQBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  13

文献信息

• Alpha(trifluoromethyl-substituted aryloxy, arylamino, arylthio or arylmethyl)-trifluoromethyl-substituted phenylacetic acids and derivatives as antidiabetic agents
  申请人：Zhao Zuchun

  公开号：US20050222213A1

  公开（公告）日：2005-10-06

  Compounds having a formula: or a pharmaceutically acceptable salt or prodrug thereof, are provided, and are useful for the treatment of metabolic disorders.

  提供具有以下公式的化合物：或其药物可接受的盐或前药，可用于治疗代谢性疾病。
• Methods For Avoiding Edema in the Treatment of Metabolic, Inflammatory, and Cardiovascular Disorders
  申请人：Sanders Martin E.

  公开号：US20080194646A1

  公开（公告）日：2008-08-14

  Compounds, compositions, and methods of treating or preventing PPARγ-mediated diseases, including cancer, using phenoxy acetic acid derivatives and prodrugs are provided.

  本发明提供了使用苯氧乙酸衍生物及其前药治疗或预防PPARγ介导的疾病，包括癌症的化合物、组合物和方法。
• Method for Avoiding Edema in the Treatment or Prevention of Ppary-Responsive Diseases, Including Cancer
  申请人：Sanders Martin E.

  公开号：US20080269189A1

  公开（公告）日：2008-10-30

  Compounds, compositions, and methods of avoiding edema while treating or preventing PPARγ-mediated diseases, including cancer, using derivatives and prodrugs are provided.

  本发明提供了使用衍生物和前药处理或预防PPARγ介导的疾病（包括癌症）时避免水肿的化合物、组合物和方法。
• ALPHA-(TRIFLUOROMETHYL-SUBSTITUTED ARYLOXY, ARYLAMINO, ARYLTHIO OR ARYLMETHYL)-TRIFLUOROMETHYL-SUBSTITUTED PHENYLACETIC ACIDS AND DERIVATIVES AS ANTIDIABETIC AGENTS
  申请人：Zhao Zuchun

  公开号：US20080287441A1

  公开（公告）日：2008-11-20

  Compounds having a formula: or a pharmaceutically acceptable salt or prodrug thereof, are provided, and are useful for the treatment of metabolic disorders.

  提供一种具有以下公式的化合物，或其药学上可接受的盐或前药，它们有助于治疗代谢性疾病。
• US7371888B2
  申请人：——

  公开号：US7371888B2

  公开（公告）日：2008-05-13