1,4-Dihydroxy-5,7-dimethoxy-naphthalin | 91963-81-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1,4-Dihydroxy-5,7-dimethoxy-naphthalin
• 英文别名: 5,7-Dimethoxynaphthalene-1,4-diol
• CAS: 91963-81-4
• 化学式: C₁₂H₁₂O₄
• 分子量: 220.225
• InChiKey: XPLMDOBNCQZBGT-UHFFFAOYSA-N

物化性质

• 沸点：
  459.7±40.0 °C(Predicted)
• 密度：
  1.307±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,4-Dihydroxy-5,7-dimethoxy-naphthalin 在 盐酸 、 三乙胺 、 silver(l) oxide 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Structural analogues of the michellamine anti-HIV agents. Importance of the tetrahydroisoquinoline rings for biological activity

  摘要：

  A series of michellamine structural analogues was prepared in which the tetrahydroisoquinoline rings were substituted with a variety of simple aromatic ring systems. Additionally, the methyl groups on the central bis-naphthalene cores were replaced with hydrogen and methoxy. All the analogues were devoid of anti-HIV activity, suggesting that the heterocyclic portion of the tetrahydroisoquinoline ring is crucial for biological activity. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)10057-9
• 作为产物：
  描述：

  1,4,4a,8a-Tetrahydro-1,3-dimethoxy-1,4-ethano-naphthalindion-(5,8) 在 palladium on activated charcoal 氢气 作用下， 生成 1,4-Dihydroxy-5,7-dimethoxy-naphthalin
  参考文献：
  名称：

  566.环己二烯的反应。第三部分 某些1-甲氧基环己-1,3-二烯转化为多环醌

  摘要：

  DOI：

  10.1039/jr9640002941

文献信息

• Krohn, Karsten; Vitz, Juergen, Advanced Synthesis and Catalysis, 2000, vol. 342, # 8, p. 825 - 827
  作者：Krohn, Karsten、Vitz, Juergen

  DOI：——

  日期：——
• CHORN, T. A.;GILES, R. G. F.;GREEN, N. R.;HUGO, V. I.;MITCHELL, P. R. K.;+, J. CHEM. SOC. PERKIN TRANS., 1984, N 6, 1339-1343
  作者：CHORN, T. A.、GILES, R. G. F.、GREEN, N. R.、HUGO, V. I.、MITCHELL, P. R. K.、+

  DOI：——

  日期：——
• Structural analogues of the michellamine anti-HIV agents. Importance of the tetrahydroisoquinoline rings for biological activity
  作者：Heping Zhang、David E Zembower、Zhidong Chen

  DOI：10.1016/s0960-894x(97)10057-9

  日期：1997.10

  A series of michellamine structural analogues was prepared in which the tetrahydroisoquinoline rings were substituted with a variety of simple aromatic ring systems. Additionally, the methyl groups on the central bis-naphthalene cores were replaced with hydrogen and methoxy. All the analogues were devoid of anti-HIV activity, suggesting that the heterocyclic portion of the tetrahydroisoquinoline ring is crucial for biological activity. (C) 1997 Elsevier Science Ltd.
• 566. Reactions of cyclohexadienes. Part III. Conversion of some 1-methoxycyclohexa-1,3-dienes into polycyclic quinones
  作者：A. J. Birch、D. N. Butler、J. B. Siddall

  DOI：10.1039/jr9640002941

  日期：——