5-methyl-4-(phenylthio)-1-tosyl-1,2,3,6-tetrahydro-2-pyridinone | 1571061-66-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-methyl-4-(phenylthio)-1-tosyl-1,2,3,6-tetrahydro-2-pyridinone
• CAS: 1571061-66-9
• 化学式: C₁₉H₁₉NO₃S₂
• 分子量: 373.497
• InChiKey: AWJAMPVJVOSSTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.98
• 重原子数：
  25.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  54.45
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  5-methyl-4-(phenylthio)-1-tosyl-1,2,3,6-tetrahydro-2-pyridinone 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以75%的产率得到5-methyl-4-(phenylthio)-1-tosyl-1,2,5,6-tetrahydro-2-pyridinone
  参考文献：
  名称：

  Formal synthesis of (±)-indolizidine 209B

  摘要：

  A new method for the synthesis of cis-C-8 methylated indolizidines and quinolizidines has been developed. Straightforward transformations including an isomerization to the trans configuration led to a formal synthesis of (+/-)-indolizidine 209B. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.08.015
• 作为产物：
  描述：

  5-methyl-4-(phenylthio)-1-tosyl-1,2,5,6-tetrahydro-2-pyridinone 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 5-methyl-4-(phenylthio)-1-tosyl-1,2,3,6-tetrahydro-2-pyridinone
  参考文献：
  名称：

  Formal synthesis of (±)-indolizidine 209B

  摘要：

  A new method for the synthesis of cis-C-8 methylated indolizidines and quinolizidines has been developed. Straightforward transformations including an isomerization to the trans configuration led to a formal synthesis of (+/-)-indolizidine 209B. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.08.015

文献信息

• Synthesis and reactions of sulfur-substituted α,β-unsaturated δ- and γ-lactones
  作者：Shang-Shing P. Chou、Wan-Shiuan Wu

  DOI：10.1016/j.tet.2014.01.062

  日期：2014.3

  method for the preparation of sulfur-substituted α,β-unsaturated δ- and γ-lactones has been developed by reaction of the allylic bromides of 5,6-dihydro-2-pyridinones with NaOH in refluxing MeOH or t-BuOH. The substituents at C5 and C6 of these substrates are very important for the success of this reaction. Some synthetic transformations of the α,β-unsaturated δ-lactones have also been carried out.

  5,6-二氢-2-吡啶酮的烯丙基溴化物与NaOH在MeOH或t- BuOH回流条件下反应制得了一种新的合成方法，用于制备硫取代的α，β-不饱和δ-和γ-内酯。。这些底物的C5和C6处的取代基对于该反应的成功非常重要。还进行了α，β-不饱和δ-内酯的一些合成转化。