2-fluoro-6-methyl-9H-fluoren-9-one | 1296670-71-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2-fluoro-6-methyl-9H-fluoren-9-one
• 英文别名: 2-fluoro-6-methylfluoren-9-one
• CAS: 1296670-71-7
• 化学式: C₁₄H₉FO
• 分子量: 212.223
• InChiKey: JHNLAPIAQMQNKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.35
• 重原子数：
  16.0
• 可旋转键数：
  0.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  17.07
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  C₁₄H₁₃FN₂O 在 2,4,6-三甲基吡啶 、 N-羟基邻苯二甲酰亚胺 、 lithium perchlorate 作用下， 以 乙腈 为溶剂， 反应 3.0h， 以58%的产率得到2-fluoro-6-methyl-9H-fluoren-9-one
  参考文献：
  名称：

  N-Hydroxyphthalimide-Mediated Electrochemical Denitrogenation of Aroylhydrazides to Generate Acyl Radicals and Their Applications in the Syntheses of Fluorenones

  摘要：

  DOI：

  10.1021/acs.joc.1c01262

文献信息

• Novel Syntheses of Fluorenones via Nitrile-Directed Palladium-Catalyzed C–H and Dual C–H Bond Activation
  作者：Jung-Chih Wan、Jun-Min Huang、Yu-Huei Jhan、Jen-Chieh Hsieh

  DOI：10.1021/ol401063w

  日期：2013.6.7

  Novel procedures for the [Pd]/[Ag]/TFA system catalyzed cascade reactions of nitrile directed remote C-H and dual C-H bond activation with insertion of nitrile were developed, which afforded variously polysubstituted fluorenones in moderate to good yields with tolerance of a wide variety of substrates.
• Fluorenone Synthesis by Palladacycle-Catalyzed Sequential Reactions of 2-Bromobenzaldehydes with Arylboronic Acids
  作者：Tao-Ping Liu、Yuan-Xi Liao、Chun-Hui Xing、Qiao-Sheng Hu

  DOI：10.1021/ol200693d

  日期：2011.5.6

  A new, anionic four-electron donor-based (type I) palladacycle-catalyzed sequential reaction of 2-bromobenzaldehydes with arylboronic acids based on the addition reaction, cyclization via C-H activation-oxidation sequence is described. Our study provided an efficient access to a variety of substituted fluorenones/indenofluorenediones from readily available arylboronic acids and 2-bromobenzaldehydes.