(2S)-2-(4-chloro-2-(2-chloro-4-(methylsulfonyl)phenoxy)phenoxy)propanoic acid | 847148-49-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S)-2-(4-chloro-2-(2-chloro-4-(methylsulfonyl)phenoxy)phenoxy)propanoic acid
• 英文别名: (S)-2-(4-chloro-2-[2-chloro-4-(methylsulfonyl)phenoxy]phenoxy)propanoic acid；AZ12204657；(s)-2-(4-Chloro-2-[2-chloro-4-(methylsulfonyl)phenoxy]phenoxy) propanoic acid；(2S)-2-[4-chloro-2-(2-chloro-4-methylsulfonylphenoxy)phenoxy]propanoic acid
• CAS: 847148-49-6
• 化学式: C₁₆H₁₄Cl₂O₆S
• 分子量: 405.256
• InChiKey: QMDOBCGDJDENNL-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  98.3
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] COMPOUNDS FOR USE AS RADIOLIGANDS<br/>[FR] COMPOSÉS DESTINÉS À ÊTRE UTILISÉS EN TANT QUE RADIOLIGANDS
  申请人：ASTRAZENECA AB

  公开号：WO2018229083A1

  公开（公告）日：2018-12-20

  The present invention relates to compounds, in particular those of formula (I) and formula (II) described herein, or pharmaceutically acceptable salts or solvates thereof, which may be used as radioligands in in vitro, ex vivo and in vivo beta cell imaging (BMI) methods, in particular as GPR44 radioligands for visualizing pancreatic beta cells. The invention also relates to a process for preparing the radioligands of formula (I) or formula (II), as well as compounds of formula (III), (IV) and (V) described herein, or pharmaceutically acceptable salts or solvates thereof, useful in the preparation of the compounds of formula (I) and formula (II).

  本发明涉及化合物，特别是本文描述的式(I)和式(II)的化合物，或其药学上可接受的盐或溶剂，可用作体外、体外和体内胰岛β细胞成像(BMI)方法中的放射配体，特别是作为GPR44放射配体用于可视化胰岛β细胞。该发明还涉及一种制备式(I)或式(II)的放射配体的方法，以及本文描述的式(III)、(IV)和(V)的化合物，或其药学上可接受的盐或溶剂，用于制备式(I)和式(II)的化合物。
• Phenoxiacetic acid derivatives
  申请人：Bonnert Victor Roger

  公开号：US20060293352A1

  公开（公告）日：2006-12-28

  The invention relates to certain 2-substituted phenoxyacetic acid derivatives of formula (I), in which the variables are as defined in the claims, useful in the treatment of diseases or conditions in which modulation of the CRTh2 receptor is beneficial, such as asthma and rhinitis.

  本发明涉及公式（I）中某些2-取代的苯氧基乙酸衍生物，其中变量如权利要求所定义，在调节CRTh2受体有益的疾病或病症的治疗中有用，例如哮喘和鼻炎。
• PHENOXIACETIC ACID DERIVATIVES
  申请人：Bonnert Roger Victor

  公开号：US20110281898A1

  公开（公告）日：2011-11-17

  The invention relates to substituted phenoxyacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.

  本发明涉及用于治疗呼吸系统疾病的取代苯氧乙酸类药物化合物，包含它们的制药组合物以及它们的制备方法。
• PHENOXYACETIC ACID DERIVATIVES
  申请人：AstraZeneca AB

  公开号：EP1660431A2

  公开（公告）日：2006-05-31
• JP2007502806A
  申请人：——

  公开号：JP2007502806A

  公开（公告）日：2007-02-15