5-(4'-bromobutoxy)-2-nitrobenzyl alcohol | 1354033-66-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(4'-bromobutoxy)-2-nitrobenzyl alcohol
• 英文别名: [5-(4-Bromobutoxy)-2-nitrophenyl]methanol
• CAS: 1354033-66-1
• 化学式: C₁₁H₁₄BrNO₄
• 分子量: 304.14
• InChiKey: ZUWWBBRCIJYBGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  75.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-(4'-bromobutoxy)-2-nitrobenzyl alcohol 、 三苯基膦 以 乙腈 为溶剂， 反应 24.0h， 以93%的产率得到{4-[3'-(hydroxymethyl)-4'-nitrophenoxy]butyl}triphenylphosphonium bromide
  参考文献：
  名称：

  Selective Uncoupling of Individual Mitochondria within a Cell Using a Mitochondria-Targeted Photoactivated Protonophore

  摘要：

  Depolarization of an individual mitochondrion or small clusters of mitochondria within cells has been achieved using a photoactivatable probe. The probe is targeted to the matrix of the mitochondrion by an alkyltriphenylphosphonium lipophilic cation and releases the protonophore 2,4-dinitrophenol locally in predeter mined regions in response to directed irradiation with UV light via a local photolysis system. This also provides a proof of principle for the general temporally and spatially controlled release of bioactive molecules, pharmacophores, or toxins to mitochondria with tissue, cell, or mitochondrion specificity.

  DOI：

  10.1021/ja2077922
• 作为产物：
  描述：

  5-(4'-bromobutoxy)-2-nitrobenzaldehyde 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 以86%的产率得到5-(4'-bromobutoxy)-2-nitrobenzyl alcohol
  参考文献：
  名称：

  Selective Uncoupling of Individual Mitochondria within a Cell Using a Mitochondria-Targeted Photoactivated Protonophore

  摘要：

  Depolarization of an individual mitochondrion or small clusters of mitochondria within cells has been achieved using a photoactivatable probe. The probe is targeted to the matrix of the mitochondrion by an alkyltriphenylphosphonium lipophilic cation and releases the protonophore 2,4-dinitrophenol locally in predeter mined regions in response to directed irradiation with UV light via a local photolysis system. This also provides a proof of principle for the general temporally and spatially controlled release of bioactive molecules, pharmacophores, or toxins to mitochondria with tissue, cell, or mitochondrion specificity.

  DOI：

  10.1021/ja2077922

文献信息

• BLOCK COPOLYMER COMPRISING PHOTO-SENSITIVE GROUP
  申请人：LG CHEM, LTD.

  公开号：EP3736302A1

  公开（公告）日：2020-11-11

  The present application may provide a block copolymer and a use thereof. The present application may provide a block copolymer and a use thereof. The block copolymer of the present application may have excellent self-assembly properties or phase separation characteristics and simultaneously have characteristics capable of changing the self-assembly structure formed once, or provide a block copolymer capable of forming a pattern of phase separation structures in a polymer membrane.

  本申请可提供一种嵌段共聚物及其用途。本申请可提供一种嵌段共聚物及其用途。本申请的嵌段共聚物可能具有优异的自组装特性或相分离特性，同时具有能够改变一次形成的自组装结构的特性，或提供一种能够在聚合物膜中形成相分离结构模式的嵌段共聚物。
• Block copolymer containing photo-sensitive moiety
  申请人：LG Chem, Ltd.

  公开号：US11111331B2

  公开（公告）日：2021-09-07

  The present application may provide a block copolymer and a use thereof. The present application may provide a block copolymer and a use thereof. The block copolymer of the present application may have excellent self-assembly properties or phase separation characteristics and simultaneously have characteristics capable of changing the self-assembly structure formed once, or provide a block copolymer capable of forming a pattern of phase separation structures in a polymer membrane.

  本申请可提供一种嵌段共聚物及其用途。本申请可提供一种嵌段共聚物及其用途。本申请的嵌段共聚物可能具有优异的自组装特性或相分离特性，同时具有能够改变一次形成的自组装结构的特性，或提供一种能够在聚合物膜中形成相分离结构模式的嵌段共聚物。
• Block Copolymer Containing Photo-sensitive Moiety
  申请人：LG Chem, Ltd.

  公开号：US20200040122A1

  公开（公告）日：2020-02-06

  The present application may provide a block copolymer and a use thereof. The present application may provide a block copolymer and a use thereof. The block copolymer of the present application may have excellent self-assembly properties or phase separation characteristics and simultaneously have characteristics capable of changing the self-assembly structure formed once, or provide a block copolymer capable of forming a pattern of phase separation structures in a polymer membrane.
• Block Copolymer Containing Photo-Sensitive Moiety
  申请人：LG Chem, Ltd.

  公开号：US20210047455A1

  公开（公告）日：2021-02-18

  A block copolymer and a use thereof is provided. The block copolymer may have excellent self-assembly properties or phase separation characteristics and simultaneously have characteristics capable of changing the self-assembly structure formed once, or provide a block copolymer capable of forming a pattern of phase separation structures in a polymer membrane.