| 1374852-95-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• CAS: 1374852-95-5
• 化学式: C₃₄H₄₈N₄O₇
• 分子量: 624.778
• InChiKey: CRVSJNOKCRVMHS-OHULCMFMSA-N

反应信息

• 作为反应物：
  描述：

  在 劳森试剂 、 potassium phosphate 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以18%的产率得到methyl (1R,2R,4S)-7-[(1R,2R,4S)-7-[(1R,2R,4S)-7-[(1R,2R,4S)-7-[(2-methylpropan-2-yl)oxycarbonyl]-7-azabicyclo[2.2.1]heptane-2-carbothioyl]-7-azabicyclo[2.2.1]heptane-2-carbothioyl]-7-azabicyclo[2.2.1]heptane-2-carbothioyl]-7-azabicyclo[2.2.1]heptane-2-carboxylate
  参考文献：
  名称：

  Secondary structure of homo-thiopeptides based on a bridged β-proline analogue: preferred formation of extended strand structures with trans-thioamide bonds

  摘要：

  Homo-thiopeptides of bicyclic 7-azabicyclo[2.2.1]heptane-2-endo-carboxylic acid (Ah2c), which is a conformationally constrained beta-proline mimic, were synthesized and their structures were investigated. These homo-thiopeptides showed a preference for ordered secondary structures with trans-thioamide bonds in the solid state and in solution. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.01.018