4-[(E)-2-(4-甲氧基苯基)乙烯基]-N,N-二甲基苯胺 | 2844-24-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 4-[(E)-2-(4-甲氧基苯基)乙烯基]-N,N-二甲基苯胺
• 英文名称: (E)-4'-methoxy-4-N,N-dimethylaminostilbene
• 英文别名: 4'-Methoxy-4-dimethylamino-trans-stilbene；4-Dimethylamino-4'-methoxy-trans-stilben；E-4-N,N-Dimethylamino-4'-methoxystilbene；trans-4'-Methoxy-4-dimethylamino-stilben；(E)-4-(2-(4-Methoxyphenyl)ethenyl)benzenamine, N,N-dimethyl-；4-[(E)-2-(4-methoxyphenyl)ethenyl]-N,N-dimethylaniline
• CAS: 2844-24-8
• 化学式: C₁₇H₁₉NO
• 分子量: 253.344
• InChiKey: JUYQPNFEYIPHFM-SNAWJCMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-[(E)-2-(4-甲氧基苯基)乙烯基]-N,N-二甲基苯胺 以 various solvent(s) 为溶剂， 生成 Z-4-N,N-Dimethylamino-4'-methoxystilbene
  参考文献：
  名称：

  Zaplo, O.; Stumpe, J.; Seeboth, A., Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals, 1992, vol. 213, p. 153 - 162

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲氧基苄醇 在 吡啶 、 氯化亚砜 、 sodium hydride 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 19.67h， 生成 4-[(E)-2-(4-甲氧基苯基)乙烯基]-N,N-二甲基苯胺
  参考文献：
  名称：

  含氮二苯乙烯的设计、合成、细胞毒活性和计算机研究

  摘要：

  在本研究中，设计、合成了五个系列的45种含氮二苯乙烯，包括35种新化合物，并测定了其对两种人肿瘤细胞系（K562细胞和MDA-MB-231细胞）和正常细胞系（L-02细胞）的细胞毒活性。 ）。构效关系表明， N , N-二甲氨基的引入增强了对K562细胞的细胞毒性，并且含有N-甲基哌嗪的化合物对MDA-MB-231细胞表现出更强的效力。其中，化合物NS1i对K562细胞具有极强的细胞毒性，IC 50值为0.93 μM，并且对正常细胞活力具有优异的选择性。此外，计算机靶点预测和分子对接证明醌还原酶2可能是NS1i的潜在靶点。总之，含氮二苯乙烯为发现新型高效抗癌药物提供了巨大的潜力，NS1i可能作为一个有前景的先导化合物值得进一步研究。

  DOI：

  10.1016/j.fitote.2023.105625

文献信息

• Substituted CIS- and trans-stilbenes as therapeutic agents
  申请人：Vander Jagt David L.

  公开号：US20070249647A1

  公开（公告）日：2007-10-25

  The present invention relates to method(s) of treating a subject afflicted with cancer or a precancerous condition, an inflammatory disease or condition, and/or stroke or other ischemic disease or condition, the method comprising administering to the subject or patient in need a composition comprising a therapeutically effective amount of a substituted cis or trans-stilbene.

  本发明涉及治疗患有癌症或癌前病变、炎症性疾病或病情以及中风或其他缺血性疾病或病情的方法，该方法包括向需要的受试者或患者施用含有一定治疗有效量的取代的顺式或反式-芪的组合物。
• Stilbene Derivatives And Their Use For Binding And Imaging Amyloid Plaques
  申请人：Kung F. Hank

  公开号：US20080108840A1

  公开（公告）日：2008-05-08

  This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.

  本发明涉及成像淀粉样沉积物的方法、标记化合物以及制备标记化合物用于成像淀粉样沉积物的方法。本发明还涉及化合物及制备化合物以抑制淀粉样蛋白聚集形成淀粉样沉积物的方法，以及将治疗剂输送到淀粉样沉积物的方法。
• N-TYPE SEMICONDUCTOR ELEMENT, METHOD FOR PRODUCING N-TYPE SEMICONDUCTOR ELEMENT, WIRELESS COMMUNICATION DEVICE AND PRODUCT TAG
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP3951890A1

  公开（公告）日：2022-02-09

  An object of the present invention is to provide a n-type semiconductor element having improved n-type semiconductor characteristics and excellent stability with a convenient process. The n-type semiconductor element includes; a substrate; a source electrode, a drain electrode, and a gate electrode; a semiconductor layer in contact with the source electrode and the drain electrode; a gate insulating layer for insulating the semiconductor layer from the gate electrode; and a second insulating layer positioned on the opposite side of the semiconductor layer from the gate insulating layer and in contact with the semiconductor layer; in which, the semiconductor layer contains nanocarbon, and the second insulating layer contains (a) a compound with an ionization potential in vacuum of 7.0 eV or less, and (b) a polymer.

  本发明的目的是提供一种 n 型半导体元件，它具有更好的 n 型半导体特性和出色的稳定性，而且工艺简便。该 n 型半导体元件包括：衬底；源电极、漏电极和栅电极；与源电极和漏电极接触的半导体层；用于将半导体层与栅电极绝缘的栅绝缘层；以及位于半导体层与栅绝缘层相反侧并与半导体层接触的第二绝缘层；其中，半导体层包含纳米碳，第二绝缘层包含 (a) 真空中电离电位为 7.0 eV 或以下的化合物，以及 (b) 聚合物。
• In vivo imaging of amyloid plaques in glaucoma using intravenous injectable dyes
  申请人：McKinnon J. Stuart

  公开号：US20050214222A1

  公开（公告）日：2005-09-29

  In vivo imaging may be used to assess a condition (e.g., a state of glaucoma or a state of ocular hypertension) of an eye of a living animal. A dye may be intravenously injected into the living animal. The dye may bind to amyloid in the nervous system of the animal. Images may be taken of a retina, an optic nerve head, an optic nerve, the lateral geniculate nucleus, and/or the visual cortex. Images may be taken using methods such as fluorescent angiography, magnetic resonance imaging, computed tomography, positron emission tomography, and/or single photon emission computed tomography. The condition of the eye and/or retinal ganglion cells in the eye may be assessed from one or more of the images. The condition of the eye may be assessed based on the presence of amyloid in one or more of the images.

  体内成像可用于评估活体动物眼睛的状况（如青光眼或眼压过高）。活体动物可静脉注射一种染料。染料可与动物神经系统中的淀粉样蛋白结合。可拍摄视网膜、视神经头、视神经、外侧膝状核和/或视觉皮层的图像。可使用荧光血管造影术、磁共振成像、计算机断层扫描、正电子发射断层扫描和/或单光子发射计算机断层扫描等方法拍摄图像。眼睛和/或眼睛中视网膜神经节细胞的状况可通过一张或多张图像进行评估。可根据一张或多张图像中是否存在淀粉样蛋白来评估眼睛的状况。
• Substituted <i>trans</i>-Stilbenes, Including Analogues of the Natural Product Resveratrol, Inhibit the Human Tumor Necrosis Factor Alpha-Induced Activation of Transcription Factor Nuclear Factor KappaB
  作者：Justin J. Heynekamp、Waylon M. Weber、Lucy A. Hunsaker、Amanda M. Gonzales、Robert A. Orlando、Lorraine M. Deck、David L. Vander Jagt

  DOI：10.1021/jm060630x

  日期：2006.11.30

  The transcription factor nuclear factor kappaB (NF-kappa B), which regulates expression of numerous antiinflammatory genes as well as genes that promote development of the prosurvival, antiapoptotic state is up-regulated in many cancer cells. The natural product resveratrol, a polyphenolic trans-stilbene, has numerous biological activities and is a known inhibitor of activation of NF-kappa B, which may account for some of its biological activities. Resveratrol exhibits activity against a wide variety of cancer cells and has demonstrated activity as a cancer chemopreventive against all stages, i.e., initiation, promotion, and progression. The biological activities of resveratrol are often ascribed to its antioxidant activity. Both antioxidant activity and biological activities of analogues of resveratrol depend upon the number and location of the hydroxy groups. In the present study, phenolic analogues of resveratrol and a series of substituted trans-stilbenes without hydroxy groups were compared with resveratrol for their abilities to inhibit the human tumor necrosis factor alpha-induced (TNF-alpha) activation of NF-kappa B, using the Panomics NF-kappa B stable reporter cell line 293/NF-kappa B-luc. A series of 75 compounds was screened to identify substituted trans-stilbenes that were more active than resveratrol. Dose-response studies of the most active compounds were carried out to obtain IC50 values. Numerous compounds were identified that were more active than resveratrol, including compounds that were devoid of hydroxy groups and were 100-fold more potent than resveratrol. The substituted trans-stilbenes that were potent inhibitors of the activation of NF-kappa B generally did not exhibit antioxidant activity. The results from screening were confirmed using BV-2 microglial cells where resveratrol and analogues were shown to inhibit LPS-induced COX-2 expression.