N,N'-diethyl-2-butene-1,4-diamine | 109296-20-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N'-diethyl-2-butene-1,4-diamine
• 英文别名: 2-Butene-1,4-diamine, N,N'-diethyl-；(E)-N,N'-diethylbut-2-ene-1,4-diamine
• CAS: 109296-20-0
• 化学式: C₈H₁₈N₂
• 分子量: 142.244
• InChiKey: YWWSWEIXJXYQJB-AATRIKPKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-bromomethyl-6-methoxy-benzofuran-2-carboxylic acid ethyl ester 、 N,N'-diethyl-2-butene-1,4-diamine 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以60%的产率得到N,N'-diethyl-N,N'-bis[(ethyl 6-methoxy-1-benzofuran-3-yl-2-carboxylate)methyl]but-2-ene-1,4-diamine
  参考文献：
  名称：

  Synthesis, Characterization, and Biological Activities of New Benzofuran Derivatives

  摘要：

  DOI：

  10.3987/com-07-11052
• 作为产物：
  描述：

  1,4-二溴-2-丁烯 、 乙胺 以 氯仿 为溶剂， 反应 24.0h， 以28%的产率得到N,N'-diethyl-2-butene-1,4-diamine
  参考文献：
  名称：

  Fungicidal activity of the synthetic putrescine analogue, (E)-l,4-diaminobut-2-ene, and derivatives

  摘要：

  AbstractThe putrescine analogue. (E)‐1,4‐diaminobut‐2‐ene (E‐BED), synthesized as the dihydrochloride salt, controlled five economically important crop pathogens, Erysiphe qraminis DC f.sp. hordei Marchal. Uromyces viciae‐fabae (Pers.) Schroet, Botrytis fabae Sardina, Podosphaera leucotricha (Ell. & Ev.) Salm. and Phytophthora infestans (Mont) De Bary. The Z‐isomer. Z‐BED. was also fungicidal, although less so than E‐BED. Post‐inoculation treatment with E‐BED gave greater control of powdery mildew infection on barley and rust and chocolate spot on broad bean than did pre‐inoculation application. It was also effective in vitro against Botrytis cinerea Pers. ex Fr., Pyricularia oxyzae Br. & Cav. and Pyrenophora avenae Ito & Karibay. When P. avenae was grown in the presence of E‐BED dihydrochloride at 81·5 mg litre−1, growth was reduced by 58% and there were significant reductions in soluble ornithine decarboxylase (ODC) and S‐adenosylmethionine decarboxylase (AdoMetDC) activity. These changes were accompanied by a sevenfold increase in putrescine concentration, a 60% increase in spermine concentration and a 32% reduction in spermidine concentration within the fungal tissue.

  DOI：

  10.1002/ps.2780410111

文献信息

• [EN] UREA DERIVATIVES OF AMPHOTERICIN B DERIVED FROM SECONDARY AMINES<br/>[FR] DÉRIVÉS D'URÉE DE L'AMPHOTÉRICINE B DÉRIVÉE D'AMINES SECONDAIRES
  申请人：UNIV ILLINOIS

  公开号：WO2016112243A1

  公开（公告）日：2016-07-14

  Provided are certain urea derivatives of amphotericin B (AmB) having improved therapeutic index compared to AmB. The compounds of the invention are less toxic than AmB and are useful to treat fungal infections. In certain embodiments the urea derivative of AmB is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof: wherein, independently for each occurrence: R represents methyl, ethyl, propyl, or isopropyl; R' represents methyl, ethyl, propyl, or isopropyl; or R and R', taken together with the nitrogen atom to which they are attached, represent a radical of a cyclic secondary amine. Also provided are methods for making the urea derivatives of AmB.

  提供了与两性霉素B（AmB）相比具有改善的治疗指数的某些尿素衍生物。本发明的化合物比AmB毒性更小，并且可用于治疗真菌感染。在某些实施例中，AmB的尿素衍生物是由以下式（I）表示的化合物或其药用可接受的盐：其中，对于每次出现独立地：R代表甲基、乙基、丙基或异丙基；R'代表甲基、乙基、丙基或异丙基；或R和R'与它们连接的氮原子一起表示环状二级胺的基团。还提供了制备AmB的尿素衍生物的方法。
• NOVEL COMPOUND HAVING MULTIMER STRUCTURE OF XANTHENE DERIVATIVE, COLORING COMPOSITION, INK FOR INKJET RECORDING, METHOD OF INKJET RECORDING, COLOR FILTER, AND COLOR TONER
  申请人：FUJIFILM CORPORATION

  公开号：US20140176653A1

  公开（公告）日：2014-06-26

  There is provided a compound represented by formula (1): in formula (1), L represents a divalent to tetravalent linking group; D represents a residue obtained by removing 1 to 5 hydrogen atoms from a compound represented by formula (2); m represents an integer of 1 to 10, however, each L may be the same with or different from every other L; n represents an integer of 2 to 10, however, each D may be the same with or different from every other D; and in formula (2), each of R 4 to R 24 independently represents a hydrogen atom or a substituent, provided that formula (2) has at least one or more ionic hydrophilic groups.

  提供了一种由公式(1)表示的化合物：在公式(1)中，L代表二价到四价的连接基团；D代表通过从由公式(2)表示的化合物中去除1到5个氢原子获得的残基；m代表1到10的整数，但是，每个L可以相同也可以不同于其他L；n代表2到10的整数，但是，每个D可以相同也可以不同于其他D；在公式(2)中，R4到R24中的每一个独立地代表一个氢原子或一个取代基，前提是公式(2)至少有一个或更多的离子亲水基团。
• Synthesis and characterization of a series of 3-methyl-3-{3-[1-methyl-3-aryl-2-triazenyl]propyl}-1-aryl-1-triazenes and related compounds
  作者：Jeff D Clarke、Shasta L Moser、Keith Vaughan

  DOI：10.1139/v06-074

  日期：2006.6.1

  A series of diazonium salts has been coupled to both secondary nitrogen atoms of the bis-secondary amine, N,N′-dimethyl-1,3-propanediamine (MeNHCH₂CH₂CH₂NHMe), to afford the new bistriazene series, the 3-methyl-3-3-[1-methyl-3-aryl-2-triazenyl]propyl}-1-aryl-1-triazenes (9). These compounds have been fully characterized by IR and NMR spectroscopy, with supporting data from elemental analysis and high-resolution mass spectrometry. A limited number of model compounds in the N,N-dimethyl-N-3-[1-methyl-3-aryl-2-triazenyl]propyl}amine series (10) have been synthesized to aid in the interpretation of the NMR spectra of the bistriazenes (9). A series of related compounds, the 3-ethyl-3-(E)-4-[1-ethyl-3-aryl-2-triazenyl]-2-butenyl}-1-aryl-1-triazenes (11), have been synthesized by diazonium coupling with the bis-secondary amine N,N′-diethyl-2-butene-1,4-diamine (15), and the diazonium coupling reaction with trans-N,N′-dimethycyclohexane-1,2-diamine (19) has been used to prepare another related series of bistriazenes, the 3-methyl-3-2-[1-methyl-3-aryl-2-triazenyl]cyclohexyl}-1-aryl-1-triazenes (12). The ¹H NMR spectra of these compounds are complex because of the presence of two chiral centres in the cyclohexanediamine moiety; the diastereotopic protons of the methylene groups in the cyclohexane ring are clearly distinguished in the 500 MHz spectra of these compounds.Key words: triazene, bistriazene, synthesis, nuclear magnetic resonance, propanediamine, 1,4-diamino-2-butene, cyclohexanediamine.

  一系列重氮盐与双仲胺 N,N′-二甲基-1,3-丙二胺（MeNHCH2CH2CH2NHMe）的两个仲氮原子偶联，得到了新的双三嗪系列，即 3-甲基-3-3-[1-甲基-3-芳基-2-三氮烯基]丙基}-1-芳基-1-三氮烯 (9)。这些化合物已通过红外光谱和核磁共振光谱进行了全面表征，并通过元素分析和高分辨率质谱获得了支持数据。我们合成了少量 N,N-二甲基-N-3-[1-甲基-3-芳基-2-三嗪基]丙基}胺系列的模型化合物 (10)，以帮助解释双三嗪的核磁共振光谱 (9)。一系列相关化合物，即 3-乙基-3-(E)-4-[1-乙基-3-芳基-2-三氮烯基]-2-丁烯基}-1-芳基-1-三氮烯（11），是通过重氮与双仲胺 N,N′-二乙基-2-丁烯-1,4-二胺（15）偶联合成的、与反式-N,N′-二甲基环己烷-1,2-二胺（19）的重氮偶联反应被用来制备另一系列相关的双三嗪，即 3-甲基-3-2-[1-甲基-3-芳基-2-三嗪基]环己基}-1-芳基-1-三嗪（12）。由于环己二胺分子中存在两个手性中心，这些化合物的 1H NMR 光谱非常复杂；在这些化合物的 500 MHz 光谱中，环己烷环中亚甲基的非对映质子可以清楚地区分。
• Salts of triazinic compounds with phosphorus oxyacids, and use of said compounds in self-extinguishing polymeric compositions
  申请人：MINISTERO DELL' UNIVERSITA' E DELLA RICERCA SCIENTIFICA E TECNOLOGICA

  公开号：EP0537837A1

  公开（公告）日：1993-04-21

  Salts of triazinic compounds with phosphorus oxyacids, having the general formula (I): obtained by salifying oligomeric derivatives of 2,4, 6-triamino-1,3,5-triazine with a phosphorus-containing acid. The compounds with general formula (I) find use in particular as flame-retardant additives.

  三嗪化合物与含磷氧酸盐的盐，其一般式为(I)：通过用含磷酸盐对2,4,6-三氨基-1,3,5-三嗪的寡聚衍生物进行盐化而获得。具有一般式(I)的化合物特别用作阻燃添加剂。
• Bis-naphthalimides as anticancer agents
  申请人：Du Pont Merck Pharmaceutical Company

  公开号：US05086059A1

  公开（公告）日：1992-02-04

  There are provided novel bis-napthalimide compounds useful as antitumor agents, pharmaceutical compositions containing them and processes for preparing intermediates to such compounds.

  提供了一种新型的双萘酰亚胺化合物，可用作抗肿瘤剂，其中包含了含有它们的制药组合物和制备这种化合物的中间体的过程。

表征谱图