N-cyclopropyl-1-[3-(6-isopropylsulfonylpyridin-3-yl)phenyl]-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide | 477252-21-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-cyclopropyl-1-[3-(6-isopropylsulfonylpyridin-3-yl)phenyl]-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide
• 英文别名: N-cyclopropyl-4-oxo-1-[3-(6-propan-2-ylsulfonylpyridin-3-yl)phenyl]-1,8-naphthyridine-3-carboxamide
• CAS: 477252-21-4
• 化学式: C₂₆H₂₄N₄O₄S
• 分子量: 488.567
• InChiKey: MAYSHBPOOKHIIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  118
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Method of preparing inhibitors of phosphodiesterase-4
  申请人：——

  公开号：US20040102472A1

  公开（公告）日：2004-05-27

  In one aspect, the present invention is directed to a one pot method of preparing intermediates of Formula V, which are useful in making inhibitors of phosphodiesterase-4: 1 The present invention is also directed to a method of preparing phosphodiesterase inhibitors comprising the Formula 2

  在一个方面，本发明涉及一种制备Formula V中间体的一锅法，该中间体在制备磷酸二酯酶-4抑制剂时非常有用： 另外，本发明还涉及一种制备磷酸二酯酶抑制剂的方法，包括Formula 2。
• Method of preparing inhibitors phosphodiesterase-4
  申请人：Albaneze-Walker Jennifer

  公开号：US20060019981A1

  公开（公告）日：2006-01-26

  In one aspect, the present invention is directed to a one pot method of preparing intermediates of Formula (V), which are useful in making inhibitors of phosphodiesterase-4: The present invention is also directed to a method of preparing phosphodiesterase inhibitors comprising the Formula (IX, IXa)

  在某个方面，本发明涉及一种制备公式（V）中间体的一锅法，该中间体在制备磷酸二酯酶-4抑制剂时非常有用：本发明还涉及一种制备公式（IX，IXa）的磷酸二酯酶抑制剂的方法。
• US7312334B2
  申请人：——

  公开号：US7312334B2

  公开（公告）日：2007-12-25
• [EN] METHOD OF PREPARING INHIBITORS OF PHOSPHODIESTERASE-4<br/>[FR] PROCEDE DE PREPARATION D'INHIBITEURS DE PHOSPHODIESTERASE-4
  申请人：MERCK & CO INC

  公开号：WO2004048377A2

  公开（公告）日：2004-06-10

  In one aspect, the present invention is directed to a one pot method of preparing intermediates of Formula (V), which are useful in making inhibitors of phosphodiesterase-4. The present invention is also directed to a method of preparing phosphodiesterase inhibitors comprising the Formula (IX, IXa).