ImpA2'p5'A sodium salt | 95313-99-8

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: ImpA2'p5'A sodium salt
• 英文别名: Imp5'A2'p5'A
• CAS: 95313-99-8
• 化学式: C₂₃H₂₇N₁₂O₁₂P₂*Na
• 分子量: 748.478
• InChiKey: PYIOZLRNMNDPKM-LYPRKKMMSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -5.56
• 重原子数：
  50.0
• 可旋转键数：
  11.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  341.33
• 氢给体数：
  6.0
• 氢受体数：
  23.0

反应信息

• 作为反应物：
  描述：

  三乙基碳酸氢铵缓冲液 、 ImpA2'p5'A sodium salt 、 2-bromoadenosine 5'-phosphoromorpholidate sodium salt 在 lead(II) nitrate 、 1-methylimidazole buffer pH 7.5 、 nuclease P₁ 作用下， 生成
  参考文献：
  名称：

  2-Bromoadenosine-Substituted 2′,5′-Oligoadenylates Modulate Binding and Activation Abilities of Human Recombinant RNase L

  摘要：

  2-Bromoadenosine-substituted analogues of 2-5A, p5'A2'p-5'A2'p5'(br(2)A), p5'(br(2)A)2'p5'A2'p5'A, and p5'(br(2)A)2'p5'(br(2)A)2'p5'(br(2)A), were prepared via a modification of a lead ion-catalyzed ligation reaction and were subsequently converted into the corresponding 5'-triphosphates. Both binding and activation of human recombinant RNase L by various 2-bromoadenosine-substituted 2-5A analogues were examined. Among the 2-bromoadenosine-substituted 2-5A analogues, the analogue with 2-bromoadenosine residing in the 2'-terminal position, p5'A2'p5'A2'p5'(br(2)A), showed the strongest binding affinity and was as effective as 2-5A itself as an activator of RNase L. The CD spectrum of p5'A2'p5'A2'p5'(br(2)A) was superimposable on that of p5'A2'p5'A2'p5'A, indicative of an anti orientation about the base-glycoside bonds as in naturally occurring 2-5A.

  DOI：

  10.1080/07328319808004320
• 作为产物：
  描述：

  MopA2'p5'A triethylammonium salt 在 2,2'-二硫二吡啶 、 溶剂黄146 、 三苯基膦 、 sodium iodide 作用下， 以 二甲基亚砜 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.67h， 生成 ImpA2'p5'A sodium salt
  参考文献：
  名称：

  Expedient chemical synthesis of sequence-specific 2',5'-oligonucleotides

  摘要：

  DOI：

  10.1021/jo00209a014