(S)-2-(di(3,5-di-t-butyl-phenyl)phosphino)-2'-methoxy-1,1'-binaphthyl | 639808-47-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-2-(di(3,5-di-t-butyl-phenyl)phosphino)-2'-methoxy-1,1'-binaphthyl
• 英文别名: Bis(3,5-ditert-butylphenyl)-[1-(2-methoxynaphthalen-1-yl)naphthalen-2-yl]phosphane
• CAS: 639808-47-2
• 化学式: C₄₉H₅₇OP
• 分子量: 692.965
• InChiKey: MUFKEDUZYKIUQI-UHFFFAOYSA-N

物化性质

• 沸点：
  692.6±55.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  15.4
• 重原子数：
  51
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  bis[(benzyldimethylamino)chloropalladium(II)] 、 (S)-2-(di(3,5-di-t-butyl-phenyl)phosphino)-2'-methoxy-1,1'-binaphthyl 以 二氯甲烷 为溶剂， 以99%的产率得到[PdCl(C6H4CH2NMe2)((S)-2-(di(3,5-di-t-butyl-phenyl)phosphino)-2'-methoxy-1,1'-binaphthyl)]
  参考文献：
  名称：

  Structural and ¹³C NMR Studies on Palladium MOP Compounds:  A New Weak C−Pd σ-Bond Plus MOP as a Bridging Diene Ligand

  摘要：

  A new set of Pd-MOP complexes (MOP = (S)-2-diarylphosphino-1,1'-binaphthyl) has been prepared. One of these, containing MeO-MOP (=2-(diphenylphosphino)-2'-methoxy-1,1'-binaphthyl), is shown to act as a chelating ligand with a naphthyl backbone diene bridging a Pd(I)-Pd(I) bond. This bonding mode exists in both the solid and solution states. A series of chloro-Pd(II)MOP complexes containing the well-known cyclometalated N V-dimethyl benzylamine chelate have been treated with NaBArF to extract the chloride ligand. The products, starting from the H-MOP, MeO-MOP, and NC-MOP analogues, are all different. Of particular interest is the product from the H-MOP reaction in that the fourth coordination position is occupied by a weak Pd-C sigma-bond from the naphthyl backbone, on the basis of C-13 NMR data. The rate of product formation in the Pd-catalyzed hydrosilylation of styrene with SiHCl3 has been measured as a function of time for the four auxiliaries H-MOP, MeO-MOP, HO-MOP, and NC-MOP. The NC-MOP is shown to be much faster than the others, and a tentative explanation is offered.

  DOI：

  10.1021/om0496535

文献信息

• Bonding in Palladium(II) and Platinum(II) Allyl MeO- and H-MOP Complexes. Subtle Differences via ¹³C NMR
  作者：P. G. Anil Kumar、Pascal Dotta、René Hermatschweiler、Paul S. Pregosin、Alberto Albinati、Silvia Rizzato

  DOI：10.1021/om049039t

  日期：2005.3.1

  studies have shown that in both Pd(II)- and Pt(II)-allyl (modified-MOP) (MOP = (S)-2-diarylphosphino-1,1‘-binaphthyl) complexes the substituent on the MOP auxiliary can affect how the naphthyl backbone interacts with a metal center. With the MeO-MOP analogue, the metal binds the carbon in a weak η1-fashion, whereas with H-MOP it prefers an η2-binding mode. For the Pt complexes, the 1J(195Pt,13C) values proved

  13 C NMR研究表明，在Pd（II）-和Pt（II）-烯丙基（修饰的MOP）中，（MOP =（S）-2-二芳基膦基-1,1'-联萘基）络合MOP上的取代基助剂会影响萘基骨架与金属中心的相互作用。与的MeO-MOP类似物，金属结合在弱η碳1 -时尚，而用H-MOP它喜欢的η 2 -结合模式。对于Pt配合物，1 J（195 Pt，13 C）值被证明是诊断工具。两种键合方式都与金属键合相对较弱。将MOP配体结构从PPh 2修饰为P（3,5-二叔丁基苯基）2类似物可以显着地影响配位层内的键长，通过对于的PdCl（ηX射线结构数据所指示的3 -C 3 H ^ 5）（改性-MOP）。2-d NMR交换光谱可用于识别和两个最常见的类型η的区分3 -η 1 -η 3异构化方法，即，围绕烯丙基C-C键相对于周围的烯丙基M-C键的旋转的旋转。对于复杂的PdCl（η 3 -C 3 H ^ 5）（H-MOP）
• SYNTHESIS OF QUINAZOLINE COMPOUNDS
  申请人：Genentech, Inc.

  公开号：US20220081413A1

  公开（公告）日：2022-03-17

  Provided herein are methods of synthesizing quinazoline compounds comprising at least one atropisomeric center.