Methyl 4-amino-2,6-dichloronicotinate | 1806864-53-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Methyl 4-amino-2,6-dichloronicotinate
• 英文别名: methyl 4-amino-2,6-dichloropyridine-3-carboxylate
• CAS: 1806864-53-8
• 化学式: C₇H₆Cl₂N₂O₂
• 分子量: 221.04
• InChiKey: MIFISBCVMRCXAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  65.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] FUSED HETEROAROMATIC PYRROLIDINONES AS SYK INHIBITORS<br/>[FR] PYRROLIDINONES ACCOLÉS EN TANT D'INHIBITEURS DE SYK
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2011079051A1

  公开（公告）日：2011-06-30

  Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein G, L1, L2, R1, R2, R3, and R4 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, pharmaceutical compositions containing them, and their use for treating disorders, diseases, and conditions involving the immune system and inflammation, including rheumatoid arthritis, hematological malignancies, epithelial cancers (i.e., carcinomas), and other disorders, diseases, and conditions for which inhibition of SYK is indicated.