(3-Nitro-phenyl)-carbamic acid | 5167-83-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-Nitro-phenyl)-carbamic acid
• 英文别名: (3-Nitrophenyl)carbamic acid
• CAS: 5167-83-9
• 化学式: C₇H₆N₂O₄
• 分子量: 182.136
• InChiKey: WMRLMOBINDQAOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  95.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-(3-Nitro-phenyl)-carbamidsaeure-2-pyridyl-(2)-ethylester 生成 (3-Nitro-phenyl)-carbamic acid
  参考文献：
  名称：

  Berner, Joachim, Zeitschrift fur Chemie, 1983, vol. 23, # 6, p. 226

  摘要：

  DOI：

文献信息

• [EN] BENZODIAZEPINE DERIVATIVES AS CCK2/GASTRIN RECEPTOR ANTAGONISTS<br/>[FR] DÉRIVÉS DE BENZODIAZÉPINE À TITRE D'ANTAGONISTES DES RÉCEPTEURS DE CCK2/GASTRINE
  申请人：TRIO MEDICINES LTD

  公开号：WO2016020698A1

  公开（公告）日：2016-02-11

  The invention relates to benzodiazepine derivatives of formula (A) useful as CCK2/gastrin receptor antagonists, their preparation and their use in the treatment or prevention of disorders associated with CCK2/gastrin receptors, disorders caused by or associated with hypergastrinaemia, and gastric acid-related disorders.

  这项发明涉及一种公式（A）的苯二氮卓衍生物，可用作CCK2/胃泌素受体拮抗剂，其制备以及在治疗或预防与CCK2/胃泌素受体相关的疾病、由高胃泌素血症引起或相关的疾病以及胃酸相关疾病中的使用。
• [EN] CARBAZOLE AND CARBOLINE COMPOUNDS FOR USE IN THE DIAGNOSIS, TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH AMYLOID OR AMYOLID-LIKE PROTEINS<br/>[FR] COMPOSÉS DE CARBAZOLE ET DE CARBOLINE DESTINÉS À ÊTRE UTILISÉS DANS LE DIAGNOSTIC, LE TRAITEMENT, L'ATTÉNUATION OU LA PRÉVENTION DE TROUBLES ASSOCIÉS AUX PROTÉINES AMYLOÏDES ET DE TYPE AMYLOÏDE
  申请人：AC IMMUNE SA

  公开号：WO2015110263A1

  公开（公告）日：2015-07-30

  The present invention relates to novel compounds that can be employed in the diagnosis, treatment, alleviation or prevention of a group of disorders and abnormalities associated with amyloid proteins and amyloid-like proteins, such as Alzheimer's disease. Precursors for the preparation of the compounds according to the present invention are also provided.

  本发明涉及一种新型化合物，可用于诊断、治疗、缓解或预防与淀粉样蛋白和类淀粉样蛋白相关的一组疾病和异常，如阿尔茨海默病。本发明还提供了制备这些化合物的前体。
• Carbazole and Carboline Compounds for Use in the Diagnosis, Treatment, Alleviation or Prevention of Disorders Associated with Amyloid or Amyloid-Like Proteins
  申请人：AC IMMUNE SA

  公开号：US20170002005A1

  公开（公告）日：2017-01-05

  The present invention relates to novel compounds that can be employed in the diagnosis, treatment, alleviation or prevention of a group of disorders and abnormalities associated with amyloid proteins and amyloid-like proteins, such as Alzheimer's disease. Precursors for the preparation of the compounds according to the present invention are also provided.

  本发明涉及可用于诊断、治疗、缓解或预防与淀粉样蛋白和类淀粉样蛋白相关的一组疾病和异常的新化合物，如阿尔茨海默病。本发明还提供了制备这些化合物的前体。
• [EN] NEW PYRIDINE DERIVATIVES AS LEPTIN RECEPTOR MODULATOR MIMETICS<br/>[FR] NOUVEAUX DÉRIVÉS DE PYRIDINE CONVENANT COMME MIMÉTIQUES DES MODULATEURS DU RÉCEPTEUR DE LA LEPTINE
  申请人：BIOVITRUM AB PUBL

  公开号：WO2009147216A1

  公开（公告）日：2009-12-10

  The present invention relates to new compounds of formula (I), to pharmaceutical compositions comprising these compounds and to the use of these compounds as leptin receptor modulator mimetics in the preparation of medicaments against conditions associated with weight gain, type 2 diabetes and dyslipidemias.

  本发明涉及式(I)的新化合物，包含这些化合物的药物组合物，以及将这些化合物作为瘦素受体调节剂模拟物用于制备治疗与体重增加、2型糖尿病和血脂异常相关的药物。
• [EN] FUSED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF<br/>[FR] COMPOSÉS DE PYRIMIDINE FUSIONNÉS, COMPOSITIONS ET APPLICATIONS MÉDICALES ASSOCIÉES
  申请人：JUBILANT BIOSYS LTD

  公开号：WO2021062327A1

  公开（公告）日：2021-04-01

  The present disclosure relates to a class of fused pyrimidine compounds of Formula I, their stereoisomers, tautomers, pharmaceutically acceptable salts, polymorphs, solvates, and hydrates thereof. The present disclosure also relates to a process of preparation of these fused pyrimidine compounds, and to pharmaceutical compositions containing them.

  本公开涉及一类式I的融合嘧啶化合物，它们的立体异构体、互变异构体、药用可接受盐、多型体、溶剂合物和水合物。本公开还涉及制备这些融合嘧啶化合物的方法，以及含有它们的药物组合物。