2,3,4-Trimethylpyrrolidin | 51308-51-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2,3,4-Trimethylpyrrolidin
• 英文别名: 2,3,4-Trimethylpyrrolidine
• CAS: 51308-51-1
• 化学式: C₇H₁₅N
• mdl: MFCD19222298
• 分子量: 113.203
• InChiKey: YFZJBYQBYKUDMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Verfahren zur Herstellung von Pyrrolen
  申请人：BASF Aktiengesellschaft

  公开号：EP0067360A2

  公开（公告）日：1982-12-22

  Verfahren zur Herstellung von Pyrrolen durch Umsetzung von Pyrrolidinen bei 160 bis 400°C in Gegenwart von Palladiumträgerkatalysatoren, die basische Verbindungen und/oder Elemente der Gruppe Ib, IIb, Vllb, Cobalt und/oder Nickel enthalten. Die nach dem Verfahren der Erfindung hergestellten Pyrrole werden als Korrosionsinhibitoren, zur Herstellung von Schädlingsbekämpfungsmitteln, Farbstoffen oder Arzneimitteln verwendet.

  在含有碱性化合物和/或 Ib、IIb、Vllb 族元素、钴和/或镍的钯支撑催化剂存在下，使吡咯烷在 160 至 400°C 下反应制备吡咯的工艺。 本发明工艺生产的吡咯类化合物可用作缓蚀剂，也可用于生产杀虫剂、染料或药品。
• Process for preparing inhibitors of nucleoside metabolism
  申请人：Industrial Research Limited

  公开号：EP2077268A1

  公开（公告）日：2009-07-08

  The invention provides a compound of the formula: wherein Y is an unsubstituted or substituted alkyl or arylalkyl group having 1 to 8 carbon atoms, as well as a process of preparing said compound. The invention also provides a process of preparing the compound 3H,5H-pyrrolo[3,2-d]pyrimidin-4-one, comprising the step of reacting a compound of the formula (A) defined above with a reagent capable of delivering a formyl equivalent. The invention also provides a process of preparing the compound 2-amino-3H,5H-pyrrolo[3,2-d]pyrimidin-4-one, comprising the step of reacting the compound 2-(N-dimethylaminomethylene)amino-6-(2-dimethylaminovinyl)-5-nitropyrimid-4-one with a reagent capable of reducing the nitro group, to produce the compound 2-amino-3H,5H-pyrrolo[3,2-d]pyrimidin-4-one.

  本发明提供了一种式化合物： 其中 Y 是具有 1 至 8 个碳原子的未取代或取代的烷基或芳烷基，以及制备所述化合物的工艺。 本发明还提供了一种制备 3H,5H-吡咯并[3,2-d]嘧啶-4-酮化合物的工艺，包括使上式（A）定义的化合物与能够提供甲酰基当量的试剂反应的步骤。 本发明还提供了制备化合物 2-氨基-3H,5H-吡咯并[3,2-d]嘧啶-4-酮的工艺，包括化合物 2-(N-二甲氨基亚甲基)氨基-6-(2-二甲氨基乙烯基)-5-硝基嘧啶-4-酮与能够还原硝基的试剂反应生成化合物 2-氨基-3H,5H-吡咯并[3,2-d]嘧啶-4-酮的步骤。
• New utilities of amide compounds
  申请人：Yamamori Teruo

  公开号：US20080221112A1

  公开（公告）日：2008-09-11

  Compounds having an activity to enhance the expression of apoAI are provided, which are used as medicaments. Compounds of formula (I): in which ring A and Ar 1 are independently a monocyclic or bicyclic aromatic carbocyclic group or aromatic heterocyclic group, each of which may be optionally substituted, or the like; R is a hydrogen or the like; Z is oxygen or the like; Y 1 and Y 2 are a hydrogen, a lower alkyl, or the like; n is an integer of 0 to 2; the broken line is the presence or absence of a bond; and the wavy line represents a cis- or trans-geometrical isomerism with respect to the double bond; are disclosed.
• Small molecule immunopotentiators and assays for their detection
  申请人：Valiante Nicholas

  公开号：US20110104186A1

  公开（公告）日：2011-05-05

  The invention provides immunostimulatory compositions comprising a small molecule immuno-potentiator (SMIP) compound and methods of administration thereof. Also provided are methods of administering a SMIP compound in an effective amount to enhance the immune response of a subject to an antigen. Further provided are novel compositions and methods of administering SMIP compounds alone or in combination with another agent for the treatment of cancer, infectious diseases and/or allergies/asthma. In a further aspect, the invention relates generally to methods of screening for small molecule immuno-modulatory compositions.
• US7429593B2
  申请人：——

  公开号：US7429593B2

  公开（公告）日：2008-09-30