3-((1R,3S)-3-(carbamoyl(diphenyl)methyl)cyclopentyl)-1-(4-fluorobenzyl)-2-methyl-3H-imidazol-1-ium bromide | 922181-28-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-((1R,3S)-3-(carbamoyl(diphenyl)methyl)cyclopentyl)-1-(4-fluorobenzyl)-2-methyl-3H-imidazol-1-ium bromide
• 英文别名: 2-[(1S,3R)-3-[3-[(4-fluorophenyl)methyl]-2-methylimidazol-1-ium-1-yl]cyclopentyl]-2,2-diphenylacetamide;bromide
• CAS: 922181-28-0
• 化学式: Br*C₃₀H₃₁FN₃O
• 分子量: 548.498
• InChiKey: PBWRVZRSJHOACQ-DMCZFVKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.09
• 重原子数：
  36
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  51.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• NOVEL NITROGEN-CONTAINING HETEROCYCLIC COMPOUND
  申请人：Aizawa Hideyuki

  公开号：US20100152261A1

  公开（公告）日：2010-06-17

  A nitrogen-containing heterocyclic derivative represented by the following general formula (I), or a hydrate or solvate thereof, which has a selective antagonistic action on the muscarinic M 3 receptor and causes reduced cardiac side effect and thus is safe, and has superior pharmacological efficacy and prolonged action even by inhalation administration, and a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier.

  一种含氮杂环衍生物，其通式如下（I），或其水合物或溶剂化物，具有选择性拮抗肌动蛋白M3受体的作用，从而导致减少心脏副作用，因此是安全的，并且具有优越的药理学效能和通过吸入给药甚至具有长效作用，以及包含该化合物和药用可接受载体的制药组合物。
• NOVEL NITROGENATED HETEROCYCLIC COMPOUND
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP1939183A1

  公开（公告）日：2008-07-02

  A nitrogen-containing heterocyclic derivative represented by the following general formula (I), or a hydrate or solvate thereof, which has a selective antagonistic action on the muscarinic M3 receptor and causes reduced cardiac side effect and thus is safe, and has superior pharmacological efficacy and prolonged action even by inhalation administration, and a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier.

  一种由下式通式（I）代表的含氮杂环衍生物或其水合物或溶液，该衍生物对毒蕈碱类 M3 受体具有选择性拮抗作用，可减少对心脏的副作用，因此是安全的，并且具有卓越的药效，即使通过吸入给药也可延长作用时间，以及一种由该化合物和药学上可接受的载体组成的药物组合物。