(3,5-Dimethyl-phenyl)-sulfamic acid | 76008-66-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3,5-Dimethyl-phenyl)-sulfamic acid
• 英文别名: 1,3-dimethyl-5-(sulfonatoazaniumyl)benzene
• CAS: 76008-66-7
• 化学式: C₈H₁₁NO₃S
• 分子量: 201.246
• InChiKey: PHMNWQAAZNEZKL-UHFFFAOYSA-N

物化性质

• 密度：
  1.402±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  74.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3,5-dimethylanilinium butylamidosulfate 反应 8.0h， 以77%的产率得到(3,5-Dimethyl-phenyl)-sulfamic acid
  参考文献：
  名称：

  Kanetani, Fujio; Yamaguchi, Hachiro, Bulletin of the Chemical Society of Japan, 1981, vol. 54, # l0, p. 3048 - 3058

  摘要：

  DOI：

文献信息

• KANETANI FUJIO, CHEM. LETT., 1980, NO 8, 965-968
  作者：KANETANI FUJIO

  DOI：——

  日期：——
• [EN] SULFAMIC ACIDS AS INHIBITORS OF HUMAN CYTOPLASMIC PROTEIN TYROSINE PHOSPHATASES<br/>[FR] ACIDES SULFAMIQUES UTILISES COMME INHIBITEURS DE PROTEINES TYROSINES PHOSPHATASES CYTOPLASMIQUES HUMAINES
  申请人：ONTOGEN CORP

  公开号：WO2003082263A1

  公开（公告）日：2003-10-09

  The present invention relates to certain substituted sulfamic acids, which exhibit inhibitory action against Human Cytoplasmic Protein Tyrosine Phosphatases (HC-PTPs, Low Molecular Weight Protein Tyrosine Phosphatases, Orthophosphoric Monoester Phosphohydrolase; EC: 3.1.3.2). These compounds are indicated in the treatment or management of wounds and diseased tissues by acceleration of wound repair. The present invention also includes within its scope methods for the treatment of wounds by the administration of the aforesaid sulfamic acids as well as pharmaceutical compositions thereof. This invention relates to active pharmaceutical compositions that facilitate the healing of wounds and repair of tissue, and methods of making and using them. These pharmaceutical compositions, which are sulfamic acids and related compounds, inhibit Human Cytoplasmic Protein Tyrosine Phosphatases, an enzyme that impedes angiogenesis.