[3-(4-morpholin-4-yl-7-{[(2-piperidin-1-ylethyl)amino]methyl}-5H-pyrrolo[3,2-d]pyrimidin-2-yl)phenyl]methanol | 1155810-65-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: [3-(4-morpholin-4-yl-7-{[(2-piperidin-1-ylethyl)amino]methyl}-5H-pyrrolo[3,2-d]pyrimidin-2-yl)phenyl]methanol
• 英文别名: [3-[4-morpholin-4-yl-7-[(2-piperidin-1-ylethylamino)methyl]-5H-pyrrolo[3,2-d]pyrimidin-2-yl]phenyl]methanol
• CAS: 1155810-65-3
• 化学式: C₂₅H₃₄N₆O₂
• 分子量: 450.584
• InChiKey: PZINCTKCXZUJSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  89.5
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• PYRROLO[3,2-d]PYRIMIDINE COMPOUNDS AND THEIR USE AS PI3 KINASE AND mTOR KINASE INHIBITORS
  申请人：CHEN Zecheng

  公开号：US20090149458A1

  公开（公告）日：2009-06-11

  A pyrrolo[3,2-d]pyrimidine compound, such as a compound of the formula (I): or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.

  一种吡咯并[3,2-d]嘧啶化合物，例如具有以下式（I）的化合物：或其药用可接受的盐，其中构成变量如本文所定义，包括所述化合物的组合物，以及制备和使用所述化合物的方法。
• [EN] PYRROLO[3,2-D]PYRIMIDINE COMPOUNDS AND THEIR USE AS PI3 KINASE AND MTOR KINASE INHIBITORS<br/>[FR] COMPOSÉS DE PYRROLO[3,2-D]PYRIMIDINE ET LEUR UTILISATION COMME INHIBITEURS DE LA PI3 KINASE ET DE LA MTOR KINASE
  申请人：WYETH CORP

  公开号：WO2009070524A1

  公开（公告）日：2009-06-04

  A pyrrolo[3,2-d]pyrimidine compound, such as a compound of the formula (I); or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds, useful for treating PI3K-related diseases.