5-isopropyl-5-nitro-tetrahydro-[1,3]oxazine | 98428-67-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 5-isopropyl-5-nitro-tetrahydro-[1,3]oxazine
• 英文别名: 5-Isopropyl-5-nitro-tetrahydro-[1,3]oxazin；5-Nitro-5-propan-2-yl-1,3-oxazinane
• CAS: 98428-67-2
• 化学式: C₇H₁₄N₂O₃
• 分子量: 174.2
• InChiKey: MAPTWBYIMQHPMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  67.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-甲-1-硝丙烷 在 聚合甲醛 、 氨 、 水 作用下， 生成 5-isopropyl-5-nitro-tetrahydro-[1,3]oxazine 、 2-aminomethyl-3-methyl-2-nitro-butan-1-ol
  参考文献：
  名称：

  Urbanski; Kolesinska, Roczniki Chemii, 1955, vol. 29, p. 392,396

  摘要：

  DOI：

文献信息

• The Role of Bone in Chronic Rhinosinusitis
  作者：Ayesha N. Khalid、Jennifer Hunt、Joel R. Perloff、David W. Kennedy

  DOI：10.1097/00005537-200211000-00008

  日期：2002.11

  AbstractObjectives To evaluate and confirm the histological inflammatory changes that occur in bone and in the overlying mucosa in experimentally induced chronic rhinosinusitis and to evaluate differences in the inflammatory patterns that may occur with different organisms.Study Design Histological study of induced maxillary rhinosinusitis in 29 New Zealand White rabbits (15 with Pseudomonas aeruginosa, 14 with Staphylococcus aureus) 7 to 9 weeks after infection.Methods Following maxillary sinus ostial infection, unilateral chronic bacterial rhinosinusitis was induced in 29 New Zealand White Rabbits, using Pseudomonas aeruginosa (n = 15) and Staphylococcus aureus (n = 14). The pathogenic organism was confirmed by culture, and the rabbits were sacrificed at predetermined time intervals (7, 8, and 9 wk) from the time of infection. Following harvest, en bloc sinus sections were mounted, stained, and analyzed. Specific attention was given to identifying histological changes in paranasal sinus bones on both sides.Results All animals (29 of 29) demonstrated histological evidence of operative occlusion on the side of the original inoculum, and all were culture‐positive for the inoculated organism at death. Histological evidence of chronic rhinosinusitis in the inoculated sinus was demonstrated in 86% of animals (25 of 29). Evidence of chronic osteomyelitis in the noninfected side was seen in 15 of 29 animals (52%) overall, or 9 of 15 animals (60%) infected with pseudomonas and 6 of 14 (43%) animals infected with staphylococcus organisms.Conclusions The study provides further evidence that bacterial rhinosinusitis can involve bone at a distance from the site of primary infection, thereby suggesting that infectious agents may spread through bony structures in the pathogenesis of chronic rhinosinusitis.
• Urbanski et al., Bulletin de l'Academie Polonaise des Sciences, Classe 3: Mathematique, Astronomie, Physique, Chimie, Geologie et Geographie, 1955, vol. 3, p. 179,181
  作者：Urbanski et al.

  DOI：——

  日期：——