1-acryloyl-3-hydroxymethylpyrrolidine | 1248611-91-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-acryloyl-3-hydroxymethylpyrrolidine
• 英文别名: 1-[3-(Hydroxymethyl)pyrrolidin-1-yl]prop-2-en-1-one
• CAS: 1248611-91-7
• 化学式: C₈H₁₃NO₂
• 分子量: 155.197
• InChiKey: XETQKJFYJWBAHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• POLYFLUORINATED COMPOUNDS ACTING AS BRUTON'S TYROSINE KINASE INHIBITORS
  申请人：Zhejiang DTRM Biopharma Co., Ltd.

  公开号：EP3138842A1

  公开（公告）日：2017-03-08

  Provided herein are novel multi-fluoro-substituted pyrazolopyrimidine compounds or salts thereof, methods for preparing the same, and therapeutic methods by administering the compounds and formulation thereof to treat and inhibit autoimmune diseases or disorders, heteroimmune diseases or disorders, inflammatory diseases and cancers or disorders.

  本文提供了新型多氟取代吡唑嘧啶化合物或其盐类、制备方法以及通过施用化合物及其制剂来治疗和抑制自身免疫性疾病或紊乱、异种免疫性疾病或紊乱、炎症性疾病和癌症或紊乱的治疗方法。
• Polyfluorinated compounds acting as bruton tyrosine kinase inhibitors
  申请人：ZHEJIANG DTRM BIOPHARMA CO. LTD.

  公开号：US10300066B2

  公开（公告）日：2019-05-28

  Described herein is a novel series of multi-fluoro-substituted pyrazolopyrimidine compounds or salts thereof. These compounds are Bruton's tyrosine kinase (BTK) inhibitors. These compounds may possess better BTK inhibition selectivity and pharmacokinetic properties. Disclosed herein are the synthesis methods of these compounds. Disclosed herein are novel synthesis methods of the multi-fluoro-substituted benzophenone and substituted phenoxy benzene. Also disclosed are pharmaceutical compositions comprising the BTK inhibitors described herein. The present invention also relates to pharmaceutical formulations comprising the compounds described herein as active ingredients. The present invention also includes the therapeutic methods by administering the BTK inhibitors and their formulations to treat and inhibit autoimmune disease, hypersensitivity disease, inflammatory diseases and cancer.

  本文描述了一系列新型多氟取代吡唑嘧啶化合物或其盐类。这些化合物是布鲁顿酪氨酸激酶（BTK）抑制剂。这些化合物可能具有更好的 BTK 抑制选择性和药代动力学特性。本文公开了这些化合物的合成方法。本文公开了多氟取代二苯甲酮和取代苯氧基苯的新型合成方法。还公开了包含本文所述 BTK 抑制剂的药物组合物。本发明还涉及包含本文所述化合物作为活性成分的药物制剂。本发明还包括通过施用BTK抑制剂及其制剂来治疗和抑制自身免疫性疾病、超敏性疾病、炎症性疾病和癌症的治疗方法。
• POLYFLUORINATED COMPOUNDS ACTING AS BRUTON TYROSINE KINASE INHIBITORS
  申请人：He Wei

  公开号：US20170065594A1

  公开（公告）日：2017-03-09

  Described herein is a novel series of multi-fluoro-substituted pyrazolopyrimidine compounds or salts thereof. These compounds are Bruton's tyrosine kinase (BTK) inhibitors. These compounds may possess better BTK inhibition selectivity and pharmacokinetic properties. Disclosed herein are the synthesis methods of these compounds. Disclosed herein are novel synthesis methods of the multi-fluoro-substituted benzophenone and substituted phenoxy benzene. Also disclosed are pharmaceutical compositions comprising the BTK inhibitors described herein. The present invention also relates to pharmaceutical formulations comprising the compounds described herein as active ingredients. The present invention also includes the therapeutic methods by administering the BTK inhibitors and their formulations to treat and inhibit autoimmune disease, hypersensitivity disease, inflammatory diseases and cancer.
• [EN] BTK INHIBITORS<br/>[FR] INHIBITEURS DE LA BTK
  申请人：BIOGEN MA INC

  公开号：WO2021133894A1

  公开（公告）日：2021-07-01

  Provided are compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R8, R9, R11A, R11B, R12,R1, R11, A1, A2, Q1, Q2, Q3, X, W, and n are as defined herein; pharmaceutical compositions comprising said compounds or pharmaceutically acceptable salts thereof, and pharmaceutically acceptable excipients; and methods of treating a disorder responsive to inhibition of Bruton's tyrosine kinase using said compounds, or pharmaceutically acceptable salts thereof, or said pharmaceutical compositions.