(4-chloro-phenyl)-[2-(3,5-dimethyl-pyrazol-1-yl)-9-methyl-9H-purin-6-yl]carbamic acid tert-butyl ester | 1219139-23-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-chloro-phenyl)-[2-(3,5-dimethyl-pyrazol-1-yl)-9-methyl-9H-purin-6-yl]carbamic acid tert-butyl ester
• 英文别名: tert-butyl N-(4-chlorophenyl)-N-[2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-yl]carbamate
• CAS: 1219139-23-7
• 化学式: C₂₂H₂₄ClN₇O₂
• 分子量: 453.931
• InChiKey: KCTTUUBBCRDJBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  91
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] SUBSTITUTED PURINYL-PYRAZOL DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS<br/>[FR] DÉRIVÉS DE PURINYL-PYRAZOLE SUBSTITUÉS ET LEUR UTILISATION EN TANT QUE MODULATEURS DES CANAUX POTASSIQUES
  申请人：NEUROSEARCH AS

  公开号：WO2010034707A1

  公开（公告）日：2010-04-01

  This invention relates to novel substituted purinyl-pyrazol derivatives of formula (I) and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.

  本发明涉及一种新的取代嘌呤基吡唑衍生物，其化学式为(I)，以及它们作为钾通道调节剂的用途。此外，本发明还涉及用于治疗或缓解与钾通道活性相关的疾病或疾病的制药组合物。
• SUBSTITUTED PURINYL-PYRAZOL DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS
  申请人：Eriksen Birgitte L.

  公开号：US20110251217A1

  公开（公告）日：2011-10-13

  This invention relates to novel substituted purinyl-pyrazol derivatives of formula (I) and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.

  本发明涉及一种新的代替嘌呤基-吡唑衍生物(I)及其作为钾通道调节剂的用途。此外，本发明还涉及用于治疗或缓解与钾通道活性相关的疾病或疾病的药物组合物。
• US8268838B2
  申请人：——

  公开号：US8268838B2

  公开（公告）日：2012-09-18